Functional and structural brain networks in epilepsy: what have we learned?

E van Diessen, SJH Diederen, KPJ Braun… - …, 2013 - Wiley Online Library
Brain functioning is increasingly seen as a complex interplay of dynamic neural systems that
rely on the integrity of structural and functional networks. Recent studies that have …

Large scale brain models of epilepsy: dynamics meets connectomics

MP Richardson - Journal of Neurology, Neurosurgery & Psychiatry, 2012 - jnnp.bmj.com
The brain is in a constant state of dynamic change, for example switching between cognitive
and behavioural tasks, and between wakefulness and sleep. The brains of people with …

Dynamic functional network connectivity in idiopathic generalized epilepsy with generalized tonic–clonic seizure

F Liu, Y Wang, M Li, W Wang, R Li, Z Zhang… - Human brain …, 2017 - Wiley Online Library
Idiopathic generalized epilepsy (IGE) has been linked with disrupted intra‐network
connectivity of multiple resting‐state networks (RSNs); however, whether impairment is …

Network connectivity in epilepsy: resting state fMRI and EEG–fMRI contributions

M Centeno, DW Carmichael - Frontiers in neurology, 2014 - frontiersin.org
There is a growing body of evidence pointing toward large-scale networks underlying the
core phenomena in epilepsy, from seizure generation to cognitive dysfunction or response …

Effect of lateralized temporal lobe epilepsy on the default mode network

Z Haneef, A Lenartowicz, HJ Yeh, J Engel Jr… - Epilepsy & Behavior, 2012 - Elsevier
The default mode network (DMN) is composed of cerebral regions involved in conscious,
resting state cognition. The hippocampus is an essential component of this network. Here …

Altered thalamocortical functional connectivity in idiopathic generalized epilepsy

JB Kim, S Suh, WK Seo, K Oh, SB Koh, JH Kim - Epilepsia, 2014 - Wiley Online Library
Objective Aberrant thalamocortical network has been hypothesized to play a crucial role in
the fundamental pathogenesis underlying idiopathic generalized epilepsy (IGE). We aimed …

Phenotypic variability in resting-state functional connectivity: current status

CJ Vaidya, EM Gordon - Brain connectivity, 2013 - liebertpub.com
We reviewed the extant literature with the goal of assessing the extent to which resting-state
functional connectivity is associated with phenotypic variability in healthy and disordered …

[HTML][HTML] Recent advances in neuroimaging of epilepsy

AM Goodman, JP Szaflarski - Neurotherapeutics, 2021 - Elsevier
Human neuroimaging has had a major impact on the biological understanding of epilepsy
and the relationship between pathophysiology, seizure management, and outcomes. This …

Mechanisms for cognitive impairment in epilepsy: moving beyond seizures

MR Khalife, RC Scott, AE Hernan - Frontiers in neurology, 2022 - frontiersin.org
There has been a major emphasis on defining the role of seizures in the causation of
cognitive impairments like memory deficits in epilepsy. Here we focus on an alternative …

Dynamic brain network states in human generalized spike-wave discharges

C Tangwiriyasakul, S Perani, M Centeno, SN Yaakub… - Brain, 2018 - academic.oup.com
Generalized spike-wave discharges in idiopathic generalized epilepsy are conventionally
assumed to have abrupt onset and offset. However, in rodent models, discharges emerge …