Design and use of model membranes to study biomolecular interactions using complementary surface-sensitive techniques

LA Clifton, RA Campbell, F Sebastiani… - Advances in colloid and …, 2020 - Elsevier
Cellular membranes are complex structures and simplified analogues in the form of model
membranes or biomembranes are used as platforms to understand fundamental properties …

[HTML][HTML] How melittin inserts into cell membrane: conformational changes, inter-peptide cooperation, and disturbance on the membrane

J Hong, X Lu, Z Deng, S Xiao, B Yuan, K Yang - Molecules, 2019 - mdpi.com
Antimicrobial peptides (AMPs), as a key component of the immune defense systems of
organisms, are a promising solution to the serious threat of drug-resistant bacteria to public …

[HTML][HTML] Understanding the formation of supported lipid bilayers via vesicle fusion—A case that exemplifies the need for the complementary method approach

TK Lind, M Cárdenas - Biointerphases, 2016 - pubs.aip.org
In this review, the authors discuss the challenges of studying supported lipid bilayers (SLBs)
deposited by vesicle fusion in terms of (1) evaluating SLB formation and quality using quartz …

Transition between Different Diffusion Modes of Individual Lipids during the Membrane‐Specific Action of As‐CATH4 Peptides

J Wu, C Xu, Z Ye, H Chen, Y Wang, K Yang, B Yuan - Small, 2023 - Wiley Online Library
The cell membrane permeabilization ability of immune defense antimicrobial peptides
(AMPs) is widely applied in biomedicine. Although the mechanisms of peptide–membrane …

Designing melittin‐graphene hybrid complexes for enhanced antibacterial activity

X Lu, J Liu, L Gou, J Li, B Yuan… - Advanced healthcare …, 2019 - Wiley Online Library
Antimicrobial peptides (AMPs) promise a fundamental solution to the devastating threat of
drug‐resistant bacteria. However, drawbacks of AMPs (eg, poor cell membrane penetration …

[HTML][HTML] Molecular details on the intermediate states of melittin action on a cell membrane

J Liu, S Xiao, J Li, B Yuan, K Yang, Y Ma - Biochimica et Biophysica Acta …, 2018 - Elsevier
Antimicrobial peptides (AMPs) provide a promising solution to the serious threat of multidrug-
resistant bacteria or superbugs to public healthcare, due to their unique disruption to …

[HTML][HTML] A molecular architectural design that promises potent antimicrobial activity against multidrug-resistant pathogens

B Yuan, J Liu, Z Deng, L Wei, W Li, Y Dou, Z Chen… - NPG Asia …, 2021 - nature.com
Addressing the devastating threat of drug-resistant pathogens requires the discovery of new
antibiotics with advanced action mechanisms and/or novel strategies for drug design …

Individual roles of peptides PGLa and Magainin 2 in synergistic membrane poration

W Ma, S Sun, W Li, Z Zhang, Z Lin, Y Xia, B Yuan… - Langmuir, 2020 - ACS Publications
Synergy between antimicrobial peptides PGLa and Magainin 2 (MAG2) provides an efficient
way to enhance their antimicrobial ability. However, the underlying molecular mechanism of …

Graphene oxide as antibacterial sensitizer: Mechanically disturbed cell membrane for enhanced poration efficiency of melittin

S Xiao, X Lu, L Gou, J Li, Y Ma, J Liu, K Yang, B Yuan - Carbon, 2019 - Elsevier
Natural antimicrobial peptides (AMPs) promise a fundamental solution to the devastating
threat of multidrug-resistant bacteria, while drawbacks such as limited antibacterial efficiency …

Comparing the membrane-interaction profiles of two antiviral peptides: Insights into structure–function relationship

S Park, JA Jackman, NJ Cho - Langmuir, 2019 - ACS Publications
In recent years, certain amphipathic, α-helical peptides have been discovered that inhibit
medically important enveloped viruses by disrupting the lipid membrane surrounding …