Cytokine modulation in pelvic organ prolapse and urinary incontinence: from molecular insights to therapeutic targets

Y Chen, A Ullah, W Chen, J Xuan, X Huang, S Liang… - Molecular …, 2024 - Springer
Pelvic organ prolapse (POP) and urinary incontinence (UI) are common disorders that
significantly impact women's quality of life. Studies have demonstrated that cytokines …

Human multilineage 3D spheroids as a model of liver steatosis and fibrosis

P Pingitore, K Sasidharan, M Ekstrand, S Prill… - International journal of …, 2019 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is the most common liver disorder in western
countries. Despite the high prevalence of NAFLD, the underlying biology of the disease …

Effects of hemodynamic load on cardiac remodeling in fish and mammals: the value of comparative models

JB Shaftoe, TE Gillis - Journal of Experimental Biology, 2024 - journals.biologists.com
The ability of the vertebrate heart to remodel enables the cardiac phenotype to be
responsive to changes in physiological conditions and aerobic demand. Examples include …

Long-term waterborne Cu2+ exposure affects collagen metabolism in fish

Y Zhang, F Yuan, K Yan, M Zhang, Y Li, G Wang… - Aquatic Toxicology, 2023 - Elsevier
Copper pollution might have a negative effect on collagen metabolism in fish. To test this
hypothesis, we exposed an important economical fish, silver pomfret (Pampus argenteus), to …

Atrophic acne scar: a process from altered metabolism of elastic fibres and collagen fibres based on transforming growth factor‐β1 signalling

J Moon, JY Yoon, JH Yang, HH Kwon… - British Journal of …, 2019 - academic.oup.com
Background Atrophic acne scar, a persistent sequela from acne, is undesirably troubling to
many patients due to its cosmetic and psychosocial aspects. Although there have been …

Effect of genipin crosslinked chitosan scaffolds containing SDF-1 on wound healing in a rat model

CH Yao, KY Chen, MH Cheng, YS Chen… - Materials Science and …, 2020 - Elsevier
Prolonged healing is a severe problem for elderly and diabetic patients. Impaired
angiogenesis, stem cell differentiation, and migration have been shown to delay wound …

The interplay of mitochondrial oxidative stress and endoplasmic reticulum stress in cardiovascular fibrosis in obese rats

FV Souza-Neto, S Jiménez-González… - Antioxidants, 2021 - mdpi.com
We have evaluated the role of mitochondrial oxidative stress and its association with
endoplasmic reticulum (ER) stress activation in the progression of obesity-related …

Endothelial-derived extracellular vesicles from obese/hypertensive adults increase factors associated with hypertrophy and fibrosis in cardiomyocytes

HK Fandl, VP Garcia, JW Treuth… - American Journal …, 2023 - journals.physiology.org
Obesity and hypertension, independently and combined, are associated with increased risk
of heart failure and heart failure-related morbidity and mortality. Interest in circulating …

Cancer‐associated fibroblast migration in non‐small cell lung cancers is modulated by increased integrin α11 expression

M Iwai, M Tulafu, S Togo, H Kawaji… - Molecular …, 2021 - Wiley Online Library
Cancer‐associated fibroblasts (CAFs) regulate cancer progression through the modulation
of extracellular matrix (ECM) and cancer cell adhesion. While undergoing a series of …

[HTML][HTML] Effects of temperature on muscle growth and collagen deposition in zebrafish (Danio rerio)

F Lin, J Lin, X Liu, Y Yuan, G Liu, X Ye - Aquaculture Reports, 2022 - Elsevier
Collagen is a major extracellular matrix component playing pivotal roles in maintaining the
muscle growth and flesh texture of fish. Enhancement of collagen deposition in muscle by …