Sigma-1 receptor (S1R) is a multi-functional, ligand-operated protein situated in
endoplasmic reticulum (ER) membranes and changes in its function and/or expression have …

The major facilitator superfamily (MFS) is one of the largest groups of secondary active
transporters conserved from bacteria to humans. MFS proteins selectively transport a wide …

Mitochondrial dysfunction contributes to numerous health problems, including neurological
and muscular degeneration, cardiomyopathies, cancer, diabetes, and pathologies of aging …

X-ray crystallography of G protein–coupled receptors and other membrane proteins is
hampered by difficulties associated with growing sufficiently large crystals that withstand …

The lipid cubic phase or in meso method is a robust approach for crystallizing membrane
proteins for structure determination. The uptake of the method is such that it is experiencing …

Abstract The field of Membrane Protein Structural Biology has grown significantly since its
first landmark in 1985 with the first three-dimensional atomic resolution structure of a …

For some membrane proteins, detergent-mediated solubilization compromises protein
stability and functionality, often impairing biophysical and structural analyses. Hence …

Secondary active transporters exploit the electrochemical potential of solutes to shuttle
specific substrate molecules across biological membranes, usually against their …

It was first discovered in 1992 that P-glycoprotein (Pgp, ABCB1), an ATP binding cassette
(ABC) transporter, can transport phospholipids such as phosphatidylcholine,− ethanolamine …

The β1-adrenoceptor (β1AR) is a G protein-coupled receptor (GPCR) that is activated by the
endogenous agonists adrenaline and noradrenaline. We have determined the structure of …