Splicing of pre‐mRNA is an essential part of eukaryotic gene expression. Serine‐/arginine‐
rich (SR) proteins are highly conserved RNA‐binding proteins present in all metazoans and …

Serine/arginine rich splicing factor 3 (SRSF3) is an important multi-functional splicing factor,
and has attracted increasing attentions in the past thirty years. The importance of SRSF3 is …

Serine/arginine‑rich splicing factor 3 (SRSF3; also known as SRp20), an important member
of the family of SRSFs, is abnormally expressed in tumors, resulting in aberrant splicing of …

Cranial neural crest (NC) cells delaminate from the neural folds in the forebrain to the
hindbrain during mammalian embryogenesis and migrate into the frontonasal prominence …

Orofacial cleft (OFC) is a common human congenital anomaly. Epithelial-specific RNA
splicing regulators ESRP1 and ESRP2 regulate craniofacial morphogenesis and their …

Ionizing radiation (IR) has been extensively used for cancer therapy, but the radioresistance
hinders and undermines the radiotherapy efficacy in clinics greatly. Here, we reported that …

Abstract The phosphoinositide 3–kinase (PI3K) pathway regulates proliferation, survival,
and metabolism and is frequently activated across human cancers. A comprehensive …

While neural crest development is known to be transcriptionally controlled via sequential
activation of gene regulatory networks (GRNs), recent evidence increasingly implicates a …

Signaling through the platelet-derived growth factor receptor alpha (PDGFRa) plays a critical
role in craniofacial development, as mutations in PDGFRA are associated with cleft …

The platelet-derived growth factor receptor (PDGFR) family of receptor tyrosine kinases
allows cells to communicate with one another by binding to growth factors at the plasma …