The extracellular forms of the IL‐1 cytokines are active through binding to specific receptors
on the surface of target cells. IL‐1 ligands bind to the extracellular portion of their ligand …

The IL-1 cytokine family comprises 11 members (7 ligands with agonist activity, 3 receptor
antagonists and 1 anti-inflammatory cytokine) and is recognised as a key mediator of …

Summary The interleukin (IL)‐36 cytokines include 3 agonists, IL‐36α, IL‐36β, and IL‐36γ
that bind to a common receptor composed of IL‐36R and IL‐1 RA cP to stimulate …

Abstract IL-36α, IL-36β, and IL-36γ are members of the IL-1 family of cytokines that signal
through a common receptor composed of IL-36R and IL-1R/AcP to activate NF-κB and …

The activity of each member of the IL-1 family of ligands is mediated by its own receptor.
Each ligand binds specifically to the extracellular “ligand binding chain” containing three Ig …

Abstract IL-36α, IL-36β, IL-36γ, and IL-36Ra, collectively called IL-36 cytokines, are part of
the IL-1 family. IL-36α, IL-36β, and IL-36γ are IL-36 receptor (IL-36R) agonists, while IL …

Objective Interleukin (IL)-36R signalling plays a proinflammatory role in different organs
including the skin, but the expression of IL-36R ligands and their molecular function in …

Abstract The interleukin-1 (IL-1) family of cytokines and receptors are implicated in the
functioning of innate and adaptive immunity and the genesis of inflammation. They are …

The interleukin-1 (IL 1) family of ligands is associated with acute and chronic inflammation,
and plays an essential role in the non-specific innate response to infection. The biological …

Interleukin-36 (IL-36) comprises to a cytokine family consisting of four isoforms IL-36α, IL-
36β, IL-36γ, and IL-36 receptor antagonist (IL-36 Ra). These IL-36 cytokines, in turn, belong …