Abstract Organs-on-chips (OoCs) are systems containing engineered or natural miniature
tissues grown inside microfluidic chips. To better mimic human physiology, the chips are …

The liver is the largest internal organ of the body with complex microarchitecture and
function that plays critical roles in drug metabolism. Hepatotoxicity and drug-induced liver …

Here we describe a method for fabricating a primary human Small Intestine-on-a-Chip
(Intestine Chip) containing epithelial cells isolated from healthy regions of intestinal …

This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …

Abstract'Organs-on-chips' are microengineered biomimetic systems containing microfluidic
channels lined by living human cells, which replicate key functional units of living organs to …

The past three decades have seen the emergence of an endeavor called tissue engineering
and regenerative medicine in which scientists, engineers, and physicians apply tools from a …

How cells become specialized, or" mature," is important for cell and developmental biology.
While maturity is usually deemed a terminal fate, it may be more helpful to consider …

Despite the tremendous hurdles presented by the complexity of the liver's structure and
function, advances in liver physiology, stem cell biology and reprogramming, and the …

Metastasis is a complex pathophysiological process. As the main cause of cancer mortality
in humans it represents a serious challenge to both basic researchers and clinicians. Here …

Organ-on-chip devices have provided the pharmaceutical and tissue engineering worlds
much hope since they arrived and began to grow in sophistication. However, limitations for …