hydroxyanthranilic acid (3HAA) is considered to be a fleeting metabolic intermediate along
tryptophan catabolism through the kynurenine pathway. 3HAA and the rest of the kynurenine …

The nematode Caenorhabditis elegans is among the most common model systems used in
aging research owing to its simple and inexpensive culture techniques, rapid reproduction …

Caenorhabditis elegans are an important model system for research on host-microbe
interaction. Their rapid life cycle, short lifespan, and transparent body structure allow simple …

3-Hydroxyanthranilic acid (3HAA) is a metabolite in the kynurenine pathway, a canonical
pathway in tryptophan catabolism. This metabolite extends lifespan in the roundworm …

Aging is experienced by most eukaryotic organisms and age is the primary risk factor for
many of the most common causes of death in humans. Age-related diseases not only …

The kynurenine pathway is responsible for a majority of tryptophan metabolism. It has been
intricately linked to both aging and immune function, yet its exact roles in the two processes …

Production of biotherapeutic drugs in mammalian cells, recombinant proteins in particular,
may be handicapped by the limitations imposed on the cultures by metabolic burden. An …