[HTML][HTML] Adult hippocampal neurogenesis in Alzheimer's disease: A roadmap to clinical relevance
Adult hippocampal neurogenesis (AHN) drops sharply during early stages of Alzheimer's
disease (AD), via unknown mechanisms, and correlates with cognitive status in AD patients …
disease (AD), via unknown mechanisms, and correlates with cognitive status in AD patients …
Microbiota from Alzheimer's patients induce deficits in cognition and hippocampal neurogenesis
S Grabrucker, M Marizzoni, E Silajdžić, N Lopizzo… - Brain, 2023 - academic.oup.com
Alzheimer's disease is a complex neurodegenerative disorder leading to a decline in
cognitive function and mental health. Recent research has positioned the gut microbiota as …
cognitive function and mental health. Recent research has positioned the gut microbiota as …
Activation of hypothalamic-enhanced adult-born neurons restores cognitive and affective function in Alzheimer's disease
Patients with Alzheimer's disease (AD) exhibit progressive memory loss, depression, and
anxiety, accompanied by impaired adult hippocampal neurogenesis (AHN). Whether AHN …
anxiety, accompanied by impaired adult hippocampal neurogenesis (AHN). Whether AHN …
A dual “turn-on” biosensor based on AIE effect and FRET for in situ detection of miR-125b biomarker in early Alzheimer's disease
Abstract MicroRNA-125b (miR-125b) is highly associated with synaptic dysfunction and tau
hyperphosphorylation in the early pathogenesis of Alzheimer's disease (AD), making it a …
hyperphosphorylation in the early pathogenesis of Alzheimer's disease (AD), making it a …
MicroRNA-22-3p ameliorates Alzheimer's disease by targeting SOX9 through the NF-κB signaling pathway in the hippocampus
P Xia, J Chen, Y Liu, X Cui, C Wang, S Zong… - Journal of …, 2022 - Springer
Background Studies have suggested that many down-regulated miRNAs identified in the
brain tissue or serum of Alzheimer's disease (AD) patients were involved in the formation of …
brain tissue or serum of Alzheimer's disease (AD) patients were involved in the formation of …
The promise of microRNA-based therapies in Alzheimer's disease: challenges and perspectives
Multi-pathway approaches for the treatment of complex polygenic disorders are emerging as
alternatives to classical monotarget therapies and microRNAs are of particular interest in …
alternatives to classical monotarget therapies and microRNAs are of particular interest in …
Small molecule regulators of microRNAs identified by high-throughput screen coupled with high-throughput sequencing
MicroRNAs (miRNAs) regulate fundamental biological processes by silencing mRNA targets
and are dysregulated in many diseases. Therefore, miRNA replacement or inhibition can be …
and are dysregulated in many diseases. Therefore, miRNA replacement or inhibition can be …
Polyethylene microplastics cause apoptosis via the MiR-132/CAPN axis and inflammation in carp ovarian
M Zhu, H Wang, F Han, Z Cai, J Wang, M Guo - Aquatic Toxicology, 2023 - Elsevier
Microplastics (MPs) are widely distributed pollutants in the environment and accumulate in
the aquatic environment due to human activities. Carp, a common edible aquatic organism …
the aquatic environment due to human activities. Carp, a common edible aquatic organism …
[HTML][HTML] microRNA-132 regulates gene expression programs involved in microglial homeostasis
Summary microRNA-132 (miR-132), a known neuronal regulator, is one of the most robustly
downregulated microRNAs (miRNAs) in the brain of Alzheimer's disease (AD) patients …
downregulated microRNAs (miRNAs) in the brain of Alzheimer's disease (AD) patients …