Cellular signaling pathways involved in the maintenance of the equilibrium between cell
proliferation and apoptosis have emerged as rational targets that can be exploited in the …

Cancer, a disease that modern medicine has not fully understood and conquered, with its
high incidence and mortality, deprives countless patients of health and even life. According …

Depression is a serious psychiatric disorder with high prevalence, and the delayed onset of
antidepressant effects remains a limitation in the treatment of depression. This study aimed …

Casein kinase-1 alpha (CK1α) is a multifunctional protein kinase that belongs to the
serine/threonine kinases of the CK1α family. It is involved in various signaling pathways …

Rho-associated protein kinase 1 (ROCK1) is a member of the AGC family which plays
crucial roles in inflammatory diseases and cancer progression. Elevated expression of …

Abstract Hexokinase 2 (HK2) is a crucial enzyme involved in glycolysis, which converts
glucose into glucose-6-phosphate and plays a significant role in glucose metabolism. HK2 …

Cancer is a major cause of death and an impediment to increasing life expectancy
worldwide. With the aim of finding new molecules for chemotherapeutic treatment of …

For centuries, plants have been serving as sources of potential therapeutic agents. In recent
years, there has been a growing interest in investigating the effects of plant-derived …

Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase molecular target with broad
importance for drug discovery, especially in the field of cancer therapeutics. ALK belongs to …

Death-associated protein kinase 3 (DAPK3) is a serine/threonine protein kinase that
regulates apoptosis, autophagy, transcription, and actin cytoskeleton reorganization. DAPK3 …