Multipotent stem cell and current application

A Sobhani, N Khanlarkhani, M Baazm… - Acta Medica …, 2017 - acta.tums.ac.ir
Stem cells are self-renewing and undifferentiated cell types that can be differentiate into
functional cells. Stem cells can be classified into two main types based on their source of …

Concise review: amniotic fluid stem cells: the known, the unknown, and potential regenerative medicine applications

SP Loukogeorgakis, P De Coppi - Stem Cells, 2017 - academic.oup.com
The amniotic fluid has been identified as an untapped source of cells with broad potential,
which possess immunomodulatory properties and do not have the ethical and legal …

Improving translational research in sex-specific effects of comorbidities and risk factors in ischaemic heart disease and cardioprotection: position paper and …

C Perrino, P Ferdinandy, HE Bøtker… - Cardiovascular …, 2021 - academic.oup.com
Ischaemic heart disease (IHD) is a complex disorder and a leading cause of death and
morbidity in both men and women. Sex, however, affects several aspects of IHD, including …

First characterization of human amniotic fluid stem cell extracellular vesicles as a powerful paracrine tool endowed with regenerative potential

C Balbi, M Piccoli, L Barile, A Papait… - Stem cells …, 2017 - academic.oup.com
Human amniotic fluid stem cells (hAFS) have shown a distinct secretory profile and
significant regenerative potential in several preclinical models of disease. Nevertheless, little …

A tunable hydrogel system for long‐term release of cell‐secreted cytokines and bioprinted in situ wound cell delivery

A Skardal, SV Murphy, K Crowell… - … Research Part B …, 2017 - Wiley Online Library
For many cellular therapies being evaluated in preclinical and clinical trials, the mechanisms
behind their therapeutic effects appear to be the secretion of growth factors and cytokines …

Amniotic fluid and amniotic membrane stem cells: marker discovery

MG Roubelakis, O Trohatou… - Stem cells …, 2012 - Wiley Online Library
Amniotic fluid (AF) and amniotic membrane (AM) have been recently characterized as
promising sources of stem or progenitor cells. Both not only contain subpopulations with …

Small extracellular vesicles secreted from human amniotic fluid mesenchymal stromal cells possess cardioprotective and promigratory potential

K Takov, Z He, HE Johnston, JF Timms… - Basic Research in …, 2020 - Springer
Mesenchymal stromal cells (MSCs) exhibit antiapoptotic and proangiogenic functions in
models of myocardial infarction which may be mediated by secreted small extracellular …

Thymosin β4: a multi-functional regenerative peptide. Basic properties and clinical applications

AL Goldstein, E Hannappel, G Sosne… - Expert opinion on …, 2012 - Taylor & Francis
Introduction: Thymosin β4, a low molecular weight, naturally-occurring peptide plays a vital
role in the repair and regeneration of injured cells and tissues. After injury, thymosin β4, is …

Reactivating endogenous mechanisms of cardiac regeneration via paracrine boosting using the human amniotic fluid stem cell secretome

C Balbi, K Lodder, A Costa, S Moimas, F Moccia… - International journal of …, 2019 - Elsevier
Background The adult mammalian heart retains residual regenerative capability via
endogenous cardiac progenitor cell (CPC) activation and cardiomyocyte proliferation. We …

The regenerative potential of amniotic fluid stem cell extracellular vesicles: lessons learned by comparing different isolation techniques

L Antounians, A Tzanetakis, O Pellerito, VD Catania… - Scientific reports, 2019 - nature.com
Extracellular vesicles (EVs) derived from amniotic fluid stem cells (AFSCs) mediate anti-
apoptotic, pro-angiogenic, and immune-modulatory effects in multiple disease models, such …