Chronic spontaneous urticaria is characterized by a perivascular non-necrotizing cellular
infiltrate around small venules of the skin. It consists primarily of CD4 (+) lymphocytes, a …

This review presents evidence that the skin mast cell, in particular the MCTC subtype, is the
primary effector cell in urticaria. Mast cells are located in the upper dermis, the ideal situation …

The current therapeutic algorithm for chronic spontaneous urticaria (CSU), endorsed by the
international guideline, entails treatment escalation from second‐generation H1 …

Urticaria is a common clinical condition presenting with wheals (hives), angioedema, or
both. Urticaria has a complex pathogenesis, along with a high disease burden, a significant …

Objective Immunoglobulin E (IgE) and its receptor, FcɛRI, importantly contribute to the
pathophysiology of chronic spontaneous urticaria (CSU). Recent findings point to a possible …

The increasing prevalence of Metabolic syndrome (MetS) is a worldwide health problem,
and the association between MetS and skin diseases has recently attracted growing …

Background In chronic spontaneous urticaria (CSU), the guidelines recommend very limited
diagnostic procedures during the routine workup, although additional investigations might …

Biomarkers useful for the evaluation and management of patients with chronic spontaneous
urticaria (CSU) are not currently available. A review of various clinical and laboratory …

Chronic urticaria is a spontaneous or inducible group of diseases characterized by the
occurrence of wheals (and, in about half of cases, angioedema) for more than 6 weeks …

Chronic spontaneous urticaria (CSU) is defined by the appearance of wheals and a variable
presence of angioedema which persists for at least 6 weeks. It represents the most common …