Interindividual variability in drug response is a major clinical problem. Polymedication and
genetic polymorphisms modulating drug-metabolising enzyme activities (cytochromes P450 …

Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening
mucocutaneous reactions, predominantly drug induced. The mortality rates for SJS and TEN …

Importance The antiepileptic drug phenytoin can cause cutaneous adverse reactions,
ranging from maculopapular exanthema to severe cutaneous adverse reactions, which …

Importance Precise estimation of a patient's drug metabolism capacity is important for
antiseizure dose personalization. Objective To quantify the differences in plasma …

Adverse drug reactions (ADRs) are a common cause of hospital admissions (up to 19%),
with the majority of cases due to off‐target predictable drug effects (type A reactions) …

Inter-ethnic differences in drug response are all too well known. These are underpinned by a
number of factors, including pharmacogenetic differences across various ethnic populations …

Introduction: Phenytoin, a widely prescribed old-generation antiepileptic drug, requires
careful individualization of dosage to compensate for its prominent pharmacokinetic …

Phenytoin (PHT) is an antiepileptic drug widely used in the treatment of focal epilepsy and
status epilepticus, and effective in controlling focal seizures with and without tonic–clonic …

Objectives: To assess the efficiency and safety profiles of levetiracetam and (fos) phenytoin
(phenytoin or fosphenytoin) for second-line treatment of seizures by performing a meta …

It is often implied that antipsychotic-induced extrapyramidal side-effects are irrelevant to
modern psychiatric therapeutics, rendered historic by newer, better treatments. This myth …