Skeletal muscle is the largest tissue in the body and loss of its function or its regenerative
properties results in debilitating musculoskeletal disorders. Understanding the mechanisms …

The lateral plate mesoderm (LPM) forms the progenitor cells that constitute the heart and
cardiovascular system, blood, kidneys, smooth muscle lineage and limb skeleton in the …

Organoids capable of forming tissue-like structures have transformed our ability to model
human development and disease. With the notable exception of the human heart, lineage …

Early human embryonic development involves extensive lineage diversification, cell-fate
specification and tissue patterning. Despite its basic and clinical importance, early human …

The TGFβ pathway has essential roles in embryonic development, organ homeostasis,
tissue repair and disease,. These diverse effects are mediated through the intracellular …

Specification of primordial germ cells (PGCs) marks the beginning of the totipotent state.
However, without a tractable experimental model, the mechanism of human PGC (hPGC) …

Stem-cell differentiation to desired lineages requires navigating alternating developmental
paths that often lead to unwanted cell types. Hence, comprehensive developmental …

Background Human pluripotent stem cells offer the best available model to study the
underlying cellular and molecular mechanisms of human embryonic lineage specification …

Organs are composed of diverse cell types that traverse transient states during
organogenesis. To interrogate this diversity during human development, we generate a …

Abstract Development of the asymmetric amniotic sac—with the embryonic disc and
amniotic ectoderm occupying opposite poles—is a vital milestone during human embryo …