Since the proposal of Paul Ehrlich's magic bullet concept over 100 years ago, tremendous
advances have occurred in targeted therapy. From the initial selective antibody, antitoxin to …

Runx2 (runt related transcription factor 2) and Sp7 (Sp7 transcription factor 7) are crucial
transcription factors for bone development. The cotranscription factor Cbfb (core binding …

The intricate, hostile, and diverse nature of osteomyelitis (OM) poses a challenge for
complete bacterial eradication and osteogenesis promotion via conventional treatment …

Interferon regulatory factor 4 (IRF4) is a transcription factor (TF) and key regulator of immune
cell development and function. We report a recurrent heterozygous mutation in IRF4, p …

Disease-causing mutations in genes encoding transcription factors (TFs) can affect TF
interactions with their cognate DNA-binding motifs. Whether and how TF mutations impact …

Abstract Purpose of Review The purpose of this review is to summarize the different roles of
the transcription factor SP7 in regulating bone formation and remodeling, discuss current …

The residual bone tumor and defects which is caused by surgical therapy of bone tumor is a
major and important problem in clinicals. And the sequential treatment for irradiating …

Osteogenesis imperfecta (OI) is a heterogeneous heritable skeletal dysplasia characterized
by bone fragility and deformity, growth deficiency, and other secondary connective tissue …

Osteoblast differentiation is a tightly regulated process in which key transcription factors
(TFs) and their target genes constitute gene regulatory networks (GRNs) under the control of …

Although biological scaffolds containing bone morphogenetic protein-2 (BMP-2) have been
widely used for osteogenic therapy, achieving stable and controlled release of BMP-2 …