The past several years have seen dramatic leaps in our understanding of how gene
expression is rewired at the translation level during tumorigenesis to support the …

The cellular stress response corresponds to the molecular changes that a cell undergoes in
response to various environmental stimuli. It induces drastic changes in the regulation of …

We recently reported that circular RNA is efficiently translated by a rolling circle amplification
(RCA) mechanism in a cell-free Escherichia coli translation system. Recent studies have …

Cells respond to stress stimuli through coordinated changes in gene expression. The
regulation of translation is often used under these circumstances because it allows …

The'inhibitor of apoptosis'(IAP) gene family, which was discovered less than a decade ago,
encodes a group of structurally related proteins that, in addition to their ability to suppress …

Apoptosis can be induced in response to hypoxia. The severity of hypoxia determines
whether cells become apoptotic or adapt to hypoxia and survive. A hypoxic environment …

Translational control of mRNAs is a point of convergence for many oncogenic signals
through which cancer cells tune protein expression in tumorigenesis. Cancer cells rely on …

Dysregulated translation is a common feature of cancer. Uncovering its governing factors
and underlying mechanism are important for cancer therapy. Here, we report that enhancer …

Summary The PI3K/mTOR-pathway is the most commonly dysregulated pathway in
epithelial cancers and represents an important target for cancer therapeutics. Here, we show …

Expression of several inhibitor of apoptosis proteins (IAPs) was investigated in the National
Cancer Institute panel of 60 human tumor cell lines, and the expression and prognostic …