Anthracyclines have been important and effective treatments against a number of cancers
since their discovery. However, their use in therapy has been complicated by severe side …

To protect tissues and the organism from disease, potentially harmful cells are removed
through programmed cell death processes, including apoptosis and necroptosis. These …

Abstract microRNAs (miRNAs) are known as a large group of short noncoding RNAs, which
structurally consist of 19–22 nucleotides in length and functionally act as one of the main …

Background Chemotherapy is one of the most common treatment options for breast cancer
(BC) patients. However, about half of the BC patients are chemotherapeutic resistant …

Immunotherapy, designed to exploit the functions of the host immune system against tumors,
has shown considerable potential against several malignancies. However, the utility of …

Abstract Dimethylarginine dimethylaminohydrolase 1 (DDAH1) is responsible for
metabolism of an endogenous inhibitor of nitric oxide synthase (NOS), asymmetric …

Breast cancer is the most frequently diagnosed cancer among females. Gene expression
profiling methods have shown the deregulation of several genes in breast cancer samples …

Chemoresistance is a complex phenomenon responsible for failure in response to
chemotherapy agents and more than 90% of deaths in cancer patients. MicroRNAs …

Breast cancer is the most frequent cancer in women worldwide. Despite the improvement in
diagnosis and treatments, the rates of cancer relapse and resistance to therapies remain …

Objectives Resistance to chemotherapeutic drugs is a serious challenge for effective therapy
of cancers. Doxorubicin is a drug which is typically used for breast cancer treatment. Several …