Genomic studies of pediatric cancer have primarily focused on specific tumor types or high-
risk disease. Here, we used a three-platform sequencing approach, including whole …

Aldehydes are widespread in the environment, with multiple sources such as food and
beverages, industrial effluents, cigarette smoke, and additives. The toxic effects of exposure …

The neuroendocrine carcinoma of the gastrointestinal system (GIS-NEC) is a rare but highly
malignant neoplasm. We analyzed 115 cases using whole-genome/exome sequencing …

The fundamental principle of precision oncology is centralized on the identification of
therapeutically exploitable targets that provides individual patients with cancer an …

Chemotherapy is ubiquitous in first-line treatment of advanced gastric cancer, yet responses
are heterogeneous, and little is known about mediators of chemotherapy response. To move …

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an aggressive leukemia of
plasmacytoid dendritic cells (pDC). BPDCN occurs at least three times more frequently in …

Among the pleotropic roles of transforming growth factor–β (TGFβ) signaling in cancer, its
impact on genomic stability is least understood. Inhibition of TGFβ signaling increases use of …

The normally antiviral enzyme APOBEC3A is an endogenous mutagen in human cancer. Its
single-stranded DNA C-to-U editing activity results in multiple mutagenic outcomes including …

Smoking is a major risk factor for bladder cancer (BC), with up to 50% of BC cases being
attributed to smoking. There are 70 known carcinogens in tobacco smoke; however, the …

Intratumour heterogeneity (ITH) is pervasive across all cancers studied and may provide the
evolving tumour multiple routes to escape immune surveillance. Immune checkpoint …