Targeting the androgen receptor (AR) signaling axis has been, over decades, the mainstay
of prostate cancer therapy. More potent inhibitors of androgen synthesis and antiandrogens …

Tumors are being increasingly perceived as abnormal organs that, in many respects,
recapitulate the outgrowth and differentiation patterns of normal tissues. In line with this idea …

Traditional therapies against cancer, chemo-and radiotherapy, have multiple limitations that
lead to treatment failure and cancer recurrence. These limitations are related to systemic …

Metastasis, the spread of malignant cells from a primary tumor to distant sites, poses the
biggest problem to cancer treatment and is the main cause of death of cancer patients. It …

Cell lineage commitment and differentiation are governed by a complex gene regulatory
network. Disruption of these processes by inappropriate regulatory signals and by …

Pancreatic ductal adenocarcinoma (PDAC), the most common type of pancreatic cancer,
has a median overall survival of 6–12 months and a 5-year survival of less than 7%. While …

Poor prognosis in lung cancer has been attributed to the presence of lung cancer stem cells
(CSCs) which resist chemotherapy and cause disease recurrence. Hence, the strong need …

The cancer stem cell (CSC) theory is gaining increasing attention from researchers and has
become an important focus of cancer research. According to the theory, a minority …

Colorectal cancer is one of the commonest cancers in the world and it is also a common
cause of cancer-related death worldwide. Despite advanced treatment strategies, the …

According to Robert Weinberg (2014),“Those who have participated in cancer research
during [the last 40 years] have witnessed wild fluctuations from times where endless …