[HTML][HTML] Structural aspects of the allergen-antibody interaction
A Pomés, GA Mueller, M Chruszcz - Frontiers in immunology, 2020 - frontiersin.org
The development of allergic disease involves the production of IgE antibodies upon allergen
exposure in a process called sensitization. IgE binds to receptors on the surface of mast …
exposure in a process called sensitization. IgE binds to receptors on the surface of mast …
[HTML][HTML] Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM
Engineered ectodomain trimer immunogens based on BG505 envelope glycoprotein are
widely utilized as components of HIV vaccine development platforms. In this study, we used …
widely utilized as components of HIV vaccine development platforms. In this study, we used …
[HTML][HTML] Molecular determinants for antibody binding on group 1 house dust mite allergens
M Chruszcz, A Pomés, J Glesner, LD Vailes… - Journal of Biological …, 2012 - ASBMB
House dust mites produce potent allergens, Der p 1 and Der f 1, that cause allergic
sensitization and asthma. Der p 1 and Der f 1 are cysteine proteases that elicit IgE …
sensitization and asthma. Der p 1 and Der f 1 are cysteine proteases that elicit IgE …
The role of water occlusion for the definition of a protein binding hot-spot
IS Moreira - Current topics in medicinal chemistry, 2015 - ingentaconnect.com
Biological systems rely on the establishment of interactions between biomolecules, which
take place in the aqueous environment of the cell. It was already demonstrated that a small …
take place in the aqueous environment of the cell. It was already demonstrated that a small …
Structural analysis of Der p 1–antibody complexes and comparison with complexes of proteins or peptides with monoclonal antibodies
Der p 1 is a major allergen from the house dust mite, Dermatophagoides pteronyssinus, that
belongs to the papain-like cysteine protease family. To investigate the antigenic …
belongs to the papain-like cysteine protease family. To investigate the antigenic …
Engineering nanoparticle antitoxins utilizing aromatic interactions
Methicillin resistant Staphylococcus aureus (MRSA) is a highly virulent bacterium capable of
inflicting severe infections. This pathogen has a long history of developing resistance to …
inflicting severe infections. This pathogen has a long history of developing resistance to …
[HTML][HTML] Yeast Surface Display Platform for Rapid Selection of an Antibody Library via Sequential Counter Antigen Flow Cytometry
B Ban, RC Blake, DA Blake - Antibodies, 2022 - mdpi.com
Yeast surface display techniques have been increasingly employed as a tool for both the
discovery and affinity maturation of antibodies. In this study, we describe the use of yeast …
discovery and affinity maturation of antibodies. In this study, we describe the use of yeast …
Development and validation of a novel leaky surface acoustic wave immunosensor array for label-free and high-sensitive detection of cyclosporin A in whole-blood …
K Chang, F Wang, Y Ding, F Pan, F Li, S Jia… - Biosensors and …, 2014 - Elsevier
This manuscript described a novel 2× 3 model of leaky surface acoustic wave (LSAW)
immunosensor array for label-free and high-sensitive detection of Cyclosporin A (CsA) in …
immunosensor array for label-free and high-sensitive detection of Cyclosporin A (CsA) in …
[HTML][HTML] Structure-guided alterations of the gp41-directed HIV-1 broadly neutralizing antibody 2F5 reveal new properties regarding its neutralizing function
J Guenaga, RT Wyatt - PLoS Pathogens, 2012 - journals.plos.org
The broadly neutralizing HIV-1 antibody 2F5 recognizes an epitope in the gp41 membrane
proximal external region (MPER). The MPER adopts a helical conformation as free peptide …
proximal external region (MPER). The MPER adopts a helical conformation as free peptide …
[HTML][HTML] Epitope predictions indicate the presence of two distinct types of epitope-antibody-reactivities determined by epitope profiling of intravenous immunoglobulins
Epitope-antibody-reactivities (EAR) of intravenous immunoglobulins (IVIGs) determined for
75,534 peptides by microarray analysis demonstrate that roughly 9% of peptides derived …
75,534 peptides by microarray analysis demonstrate that roughly 9% of peptides derived …