[HTML][HTML] Structural aspects of the allergen-antibody interaction

A Pomés, GA Mueller, M Chruszcz - Frontiers in immunology, 2020 - frontiersin.org
The development of allergic disease involves the production of IgE antibodies upon allergen
exposure in a process called sensitization. IgE binds to receptors on the surface of mast …

[HTML][HTML] Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM

A Antanasijevic, LM Sewall, CA Cottrell… - Nature …, 2021 - nature.com
Engineered ectodomain trimer immunogens based on BG505 envelope glycoprotein are
widely utilized as components of HIV vaccine development platforms. In this study, we used …

[HTML][HTML] Molecular determinants for antibody binding on group 1 house dust mite allergens

M Chruszcz, A Pomés, J Glesner, LD Vailes… - Journal of Biological …, 2012 - ASBMB
House dust mites produce potent allergens, Der p 1 and Der f 1, that cause allergic
sensitization and asthma. Der p 1 and Der f 1 are cysteine proteases that elicit IgE …

The role of water occlusion for the definition of a protein binding hot-spot

IS Moreira - Current topics in medicinal chemistry, 2015 - ingentaconnect.com
Biological systems rely on the establishment of interactions between biomolecules, which
take place in the aqueous environment of the cell. It was already demonstrated that a small …

Structural analysis of Der p 1–antibody complexes and comparison with complexes of proteins or peptides with monoclonal antibodies

T Osinski, A Pomés, KA Majorek, J Glesner… - The Journal of …, 2015 - journals.aai.org
Der p 1 is a major allergen from the house dust mite, Dermatophagoides pteronyssinus, that
belongs to the papain-like cysteine protease family. To investigate the antigenic …

Engineering nanoparticle antitoxins utilizing aromatic interactions

A Weisman, YA Chen, Y Hoshino, H Zhang… - …, 2014 - ACS Publications
Methicillin resistant Staphylococcus aureus (MRSA) is a highly virulent bacterium capable of
inflicting severe infections. This pathogen has a long history of developing resistance to …

[HTML][HTML] Yeast Surface Display Platform for Rapid Selection of an Antibody Library via Sequential Counter Antigen Flow Cytometry

B Ban, RC Blake, DA Blake - Antibodies, 2022 - mdpi.com
Yeast surface display techniques have been increasingly employed as a tool for both the
discovery and affinity maturation of antibodies. In this study, we describe the use of yeast …

Development and validation of a novel leaky surface acoustic wave immunosensor array for label-free and high-sensitive detection of cyclosporin A in whole-blood …

K Chang, F Wang, Y Ding, F Pan, F Li, S Jia… - Biosensors and …, 2014 - Elsevier
This manuscript described a novel 2× 3 model of leaky surface acoustic wave (LSAW)
immunosensor array for label-free and high-sensitive detection of Cyclosporin A (CsA) in …

[HTML][HTML] Structure-guided alterations of the gp41-directed HIV-1 broadly neutralizing antibody 2F5 reveal new properties regarding its neutralizing function

J Guenaga, RT Wyatt - PLoS Pathogens, 2012 - journals.plos.org
The broadly neutralizing HIV-1 antibody 2F5 recognizes an epitope in the gp41 membrane
proximal external region (MPER). The MPER adopts a helical conformation as free peptide …

[HTML][HTML] Epitope predictions indicate the presence of two distinct types of epitope-antibody-reactivities determined by epitope profiling of intravenous immunoglobulins

M Luštrek, P Lorenz, M Kreutzer, Z Qian, F Steinbeck… - PLoS …, 2013 - journals.plos.org
Epitope-antibody-reactivities (EAR) of intravenous immunoglobulins (IVIGs) determined for
75,534 peptides by microarray analysis demonstrate that roughly 9% of peptides derived …