The chemical senses—smell and taste—allow animals to evaluate and distinguish valuable
food resources from dangerous substances in the environment. The central mechanisms by …

Fluorescence has long been recognized as a powerful tool for probing biological structure
and function. Nearly sixty-five years ago, Coons and colleagues introduced the first …

Drosophila olfactory sensory neurons (OSNs) each express two odorant receptors (ORs): a
divergent member of the OR family and the highly conserved, broadly expressed receptor …

Summary Background: Olfactory receptor neurons (ORNs) convey chemical information into
the brain, producing internal representations of odors detected in the periphery. A …

We have undertaken a functional analysis of the odorant receptor repertoire in the
Drosophila antenna. Each receptor was expressed in a mutant olfactory receptor neuron …

Research in the fruit fly Drosophila melanogaster has led to insights in neural development,
axon guidance, ion channel function, synaptic transmission, learning and memory, diurnal …

The binding interface of calmodulin and a calmodulin binding peptide were reengineered by
computationally designing complementary bumps and holes. This redesign led to the …

The mushroom body (MB) of the insect brain has important roles in odor learning and
memory and in diverse other brain functions. To elucidate the anatomical basis underlying …

Genetically encoded Ca2+ indicators allow researchers to quantitatively measure Ca2+
dynamics in a variety of experimental systems. This protocol summarizes the indicators that …

Fruitflies show robust attraction to food odours, which usually excite several glomeruli. To
understand how the representation of such odours leads to behaviour, we used genetic …