Current understanding of the therapeutic benefits of mesenchymal stem cells in acute respiratory distress syndrome

M Lopes-Pacheco, C Robba, PRM Rocco… - Cell biology and …, 2020 - Springer
The acute respiratory distress syndrome (ARDS) is a multifaceted lung disorder in which no
specific therapeutic intervention is able to effectively improve clinical outcomes. Despite an …

[HTML][HTML] Cell therapy in acute respiratory distress syndrome

S Horie, HE Gonzalez, JG Laffey… - Journal of thoracic …, 2018 - ncbi.nlm.nih.gov
Acute respiratory distress syndrome (ARDS) is driven by a severe pro-inflammatory
response resulting in lung damage, impaired gas exchange and severe respiratory failure …

Leukocyte inclusion within a platelet rich plasma-derived fibrin scaffold stimulates a more pro-inflammatory environment and alters fibrin properties

E Anitua, M Zalduendo, M Troya, S Padilla, G Orive - PloS one, 2015 - journals.plos.org
One of the main differences among platelet-rich plasma (PRP) products is the inclusion of
leukocytes that may affect the biological efficacy of these autologous preparations. The …

Prospects for translational regenerative medicine

FM Chen, YM Zhao, Y Jin, S Shi - The Ethical Challenges of …, 2020 - taylorfrancis.com
Translational medicine is an evolutional concept that encompasses the rapid translation of
basic research for use in clinical disease diagnosis, prevention and treatment. It follows the …

Approaches to in vitro tissue regeneration with application for human disease modeling and drug development

MR Ebrahimkhani, CL Young, DA Lauffenburger… - Drug discovery today, 2014 - Elsevier
Highlights•Reliable in vitro models for human disease are needed.•Human cell-based
models including iPS cell-based models are emerging.•Biomimetic matrices and substrates …

[HTML][HTML] Uncertainty and innovation: Understanding the role of cell-based manufacturing facilities in shaping regulatory and commercialization environments

R Isasi, V Rahimzadeh, K Charlebois - Applied & translational genomics, 2016 - Elsevier
The purpose of this qualitative study is to elucidate stakeholder perceptions of, and
institutional practices related to cell-based therapies and products (CTP) regulation and …

Biomaterials in regenerative medicine: Challenges in technology transfer from science to process development

P Chandra, JJ Yoo, SJ Lee - Translational Regenerative Medicine, 2015 - Elsevier
Biomaterials have substantial value in tissue engineering and regenerative medicine, but
translating advances in biomaterials science into products with clinical applications involves …

Regenerative urology clinical trials: an ethical assessment of road blocks and solutions

AJM Oerlemans, WFJ Feitz, E van Leeuwen… - … Engineering Part B …, 2013 - liebertpub.com
Tissue engineering—part of regenerative medicine—is a promising technology that could
potentially offer elegant solutions to urogenital defects, but so far, it has fallen short of its …

Regenerative Medicine in South Korea: bridging the gap between authorization and reimbursement

DS Kim, G Lee, H Cho, SJ Bae - Frontiers in bioengineering and …, 2021 - frontiersin.org
Regenerative medicine (RM) has considerable potential to address the needs of aging-
related and uncurable diseases. However, its incorporation into reimbursement of health …

Regenerative medicine and responsible research and innovation: proposals for a responsible acceleration to the clinic

A Webster - Regenerative Medicine, 2017 - Taylor & Francis
This paper asks how regenerative medicine can be examined through the 'responsible
research and innovation'(RRI) approach which has been developed over the past decade. It …