An estimated 47 million people worldwide are living with dementia in 2015, and this number
is projected to triple by 2050. In the absence of a disease-modifying treatment or cure …

A systematic review was conducted to identify risk factors associated with the onset and
progression of Alzheimer's disease (AD). Moderate and high quality systematic reviews …

Summary At present, about 33· 9 million people worldwide have Alzheimer's disease (AD),
and prevalence is expected to triple over the next 40 years. The aim of this Review was to …

The relationship between body mass index (BMI)(in midlife and late‐life) and dementia was
investigated in meta‐analyses of 16 articles reporting on 15 prospective studies. Follow‐ups …

That the renin–angiotensin system (RAS) is involved in regulation of blood pressure,
vasoconstriction, sodium intake and potassium excretion is well established. Studies in the …

Heart disease is the major leading cause of death and disability in the world. Mainly
affecting the elderly population, heart disease and its main outcome, cardiovascular …

Background Chronic hypertension, particularly midlife high blood pressure, has been
associated with an increased risk for cognitive decline and dementia. In this context …

Increasing numbers of people are developing type 2 diabetes mellitus, but interventions to
prevent and treat the classic microvascular and macrovascular complications have …

The classic renin-angiotensin system (RAS) is described as a circulating hormone system
focused on cardiovascular and body water regulation, with angiotensin II as its major …

The classic renin–angiotensin system (RAS) was initially described as a hormone system
designed to mediate cardiovascular and body water regulation, with angiotensin II as its …