Isothermal titration calorimetry (ITC) is a biophysical technique for measuring the formation
and dissociation of molecular complexes and has become an invaluable tool in many …

Ankyrin repeat proteins are found in all three kingdoms of life. Fundamentally, these proteins
are involved in protein-protein interaction in order to activate or suppress biological …

Squamous cell carcinomas (SCCs) are one of the most frequent forms of human
malignancy, but, other than TP53 mutations, few causative somatic aberrations have been …

Intrinsically disordered regions (IDRs) play important roles in proteins that regulate gene
expression. A prominent example is the intracellular domain of the Notch receptor (NICD) …

Isothermal titration calorimetry (ITC) has become the gold-standard technique for studying
binding processes due to its high precision and sensitivity, as well as its capability for the …

The Notch-signaling pathway is involved in multiple processes during vertebrate cardiac
development. Cardiomyocyte differentiation, patterning of the different cardiac regions, valve …

Notch signaling is an evolutionarily conserved signal transduction pathway that is essential
for metazoan development. Upon ligand binding, the Notch intracellular domain (NOTCH …

In B cells infected by the cancer-associated Epstein-Barr virus (EBV), RUNX3 and RUNX1
transcription is manipulated to control cell growth. The EBV-encoded EBNA2 transcription …

Notch signaling regulates many cellular processes during development and adult tissue
renewal. Upon ligand binding, Notch receptors undergo ectodomain shedding followed by γ …

Notch is a conserved signaling pathway that is essential for metazoan development and
homeostasis; dysregulated signaling underlies the pathophysiology of numerous human …