[HTML][HTML] How genomics can help biodiversity conservation

K Theissinger, C Fernandes, G Formenti, I Bista… - Trends in Genetics, 2023 - cell.com
The availability of public genomic resources can greatly assist biodiversity assessment,
conservation, and restoration efforts by providing evidence for scientifically informed …

[HTML][HTML] The era of reference genomes in conservation genomics

G Formenti, K Theissinger, C Fernandes, I Bista… - Trends in ecology & …, 2022 - cell.com
Progress in genome sequencing now enables the large-scale generation of reference
genomes. Various international initiatives aim to generate reference genomes representing …

Building pangenome graphs

E Garrison, A Guarracino, S Heumos, F Villani, Z Bao… - Nature …, 2024 - nature.com
Pangenome graphs can represent all variation between multiple reference genomes, but
current approaches to build them exclude complex sequences or are based upon a single …

The design and construction of reference pangenome graphs with minigraph

H Li, X Feng, C Chu - Genome biology, 2020 - Springer
The recent advances in sequencing technologies enable the assembly of individual
genomes to the quality of the reference genome. How to integrate multiple genomes from …

Graph-based pan-genomes: increased opportunities in plant genomics

S Wang, YQ Qian, RP Zhao, LL Chen… - Journal of …, 2023 - academic.oup.com
Due to the development of sequencing technology and the great reduction in sequencing
costs, an increasing number of plant genomes have been assembled, and numerous …

A diploid assembly-based benchmark for variants in the major histocompatibility complex

CS Chin, J Wagner, Q Zeng, E Garrison, S Garg… - Nature …, 2020 - nature.com
Most human genomes are characterized by aligning individual reads to the reference
genome, but accurate long reads and linked reads now enable us to construct accurate …

Are we there yet? Driving the road to evolutionary graph-pangenomics

S Hübner - Current Opinion in Plant Biology, 2022 - Elsevier
With increase in the number of sequenced genomes, it is now recognized that graph-based
pangenomes can provide a comprehensive platform to study diversity in a population or …

The Practical Haplotype Graph, a platform for storing and using pangenomes for imputation

PJ Bradbury, T Casstevens, SE Jensen… - …, 2022 - academic.oup.com
Motivation Pangenomes provide novel insights for population and quantitative genetics,
genomics and breeding not available from studying a single reference genome. Instead, a …

Whole‐genome sequencing and genome regions of special interest: Lessons from major histocompatibility complex, sex determination, and plant self‐incompatibility

X Vekemans, V Castric, H Hipperson… - Molecular …, 2021 - Wiley Online Library
Whole‐genome sequencing of non‐model organisms is now widely accessible and has
allowed a range of questions in the field of molecular ecology to be investigated with greater …

Haplotype-aware variant selection for genome graphs

N Tavakoli, D Gibney, S Aluru - … of the 13th ACM International Conference …, 2022 - dl.acm.org
Graph-based genome representations have proven to be a powerful tool in genomic
analysis due to their ability to encode variations found in multiple haplotypes and capture …