Cancer neuroscience: State of the field, emerging directions

F Winkler, HS Venkatesh, M Amit, T Batchelor, IE Demir… - Cell, 2023 - cell.com
The nervous system governs both ontogeny and oncology. Regulating organogenesis
during development, maintaining homeostasis, and promoting plasticity throughout life, the …

[HTML][HTML] The neuroscience of cancer

R Mancusi, M Monje - Nature, 2023 - nature.com
The nervous system regulates tissue stem and precursor populations throughout life.
Parallel to roles in development, the nervous system is emerging as a critical regulator of …

Glioblastoma remodelling of human neural circuits decreases survival

S Krishna, A Choudhury, MB Keough, K Seo, L Ni… - Nature, 2023 - nature.com
Gliomas synaptically integrate into neural circuits,. Previous research has demonstrated
bidirectional interactions between neurons and glioma cells, with neuronal activity driving …

[HTML][HTML] Remote neuronal activity drives glioma progression through SEMA4F

E Huang-Hobbs, YT Cheng, Y Ko, E Luna-Figueroa… - Nature, 2023 - nature.com
The tumour microenvironment plays an essential role in malignancy, and neurons have
emerged as a key component of the tumour microenvironment that promotes tumourigenesis …

Tumor microenvironment in glioblastoma: Current and emerging concepts

P Sharma, A Aaroe, J Liang… - Neuro-Oncology …, 2023 - academic.oup.com
Glioblastoma (GBM) tumor microenvironment (TME) is a highly heterogeneous and complex
system, which in addition to cancer cells, consists of various resident brain and immune cells …

[HTML][HTML] Disconnecting multicellular networks in brain tumours

V Venkataramani, M Schneider, FA Giordano… - Nature Reviews …, 2022 - nature.com
Cancer cells can organize and communicate in functional networks. Similarly to other
networks in biology and sociology, these can be highly relevant for growth and resilience. In …

The interplay of autophagy and oxidative stress in the pathogenesis and therapy of retinal degenerative diseases

KC Chang, PF Liu, CH Chang, YC Lin, YJ Chen… - Cell & bioscience, 2022 - Springer
Oxidative stress is mainly caused by intracellular reactive oxygen species (ROS) production,
which is highly associated with normal physiological homeostasis and the pathogenesis of …

Neuronal hyperexcitability drives central and peripheral nervous system tumor progression in models of neurofibromatosis-1

C Anastasaki, J Mo, JK Chen, J Chatterjee… - Nature …, 2022 - nature.com
Neuronal activity is emerging as a driver of central and peripheral nervous system cancers.
Here, we examined neuronal physiology in mouse models of the tumor predisposition …

Circadian rhythms and astrocytes: the good, the bad, and the ugly

MH Hastings, M Brancaccio… - Annual review of …, 2023 - annualreviews.org
This review explores the interface between circadian timekeeping and the regulation of
brain function by astrocytes. Although astrocytes regulate neuronal activity across many time …

[HTML][HTML] Neuron–oligodendroglial interactions in health and malignant disease

KR Taylor, M Monje - Nature Reviews Neuroscience, 2023 - nature.com
Experience sculpts brain structure and function. Activity-dependent modulation of the
myelinated infrastructure of the nervous system has emerged as a dimension of adaptive …