Depression is one of the leading causes of disability, and, if left unmanaged, it can increase
the risk for suicide. The evidence base on the determinants of depression is fragmented …

Psychological stress during childhood and adolescence increases risk of health problems
across the lifecourse, and inflammation is implicated as an underlying mechanism. To …

Depression onset peaks during adolescence and young adulthood. Current treatments are
only moderately effective, driving the search for novel pathophysiological mechanisms …

Background Depression rates increase markedly for girls across the adolescent transition,
but the social‐environmental and biological processes underlying this phenomenon remain …

Early adverse experience is related to psychiatric illness that occurs decades later. The
mechanisms underlying this phenomenon have not been fully identified. There is a …

Background Chronic low-grade inflammation may play a role in the pathophysiology of
depression, at least in a subset of patients. High-sensitivity C-reactive protein (hs-CRP) has …

Background No study has investigated the role of inflammation in explaining the association
between early exposures to adverse life events and depressive symptoms in adolescence …

Background Depression has been associated with low-grade elevation of plasma cytokines
(eg interleukin-6, IL-6; tumor necrosis factor alpha, TNFα) in both cross-sectional and …

Animal models of stress and related conditions, including depression, have shown that
elevated peripheral levels of inflammatory cytokines have downstream consequences on …

Objective To examine the extent to which anxiety and depressive symptoms, self-esteem
and proinflammatory cytokines interact to significantly predict quality of life in breast cancer …