Platelet-derived growth factor (PDGF) isoforms and PDGF receptors have important
functions in the regulation of growth and survival of certain cell types during embryonal …

Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) have served as
prototypes for growth factor and receptor tyrosine kinase function for more than 25 years …

Tyrosine phosphorylation is an important signalling mechanism in eukaryotic cells. In
cancer, oncogenic activation of tyrosine kinases is a common feature, and novel anticancer …

Platelet‐derived growth factor (PDGF) isoforms and their receptors have important roles
during embryogenesis, particularly in the development of various mesenchymal cell types in …

Platelet-derived growth factor (PDGF) is a potent mitogenic and migratory factor that
regulates the tyrosine phosphorylation of a variety of signalling proteins via intracellular …

Many studies have illustrated that the production of reactive oxygen species (ROS) is
important for optimal tyrosine phosphorylation and signaling in response to diverse stimuli …

Cardiovascular diseases are a major cause of human death worldwide. Excessive
proliferation of vascular smooth muscle cells contributes to the etiology of such diseases …

PTP1B and TC-PTP are closely related protein tyrosine phosphatases, sharing 74%
homology in their catalytic domain. However, their cellular localization, function, and …

Insulin resistance is a key pathological feature of type 2 diabetes and is characterized by
defects in signaling by the insulin receptor (IR) protein tyrosine kinase. The inhibition of …

Signaling through platelet‐derived growth factor (PDGF) receptors contributes to multiple
tumor‐associated processes. The recent introduction of clinically useful PDGF inhibitors …