It is well established that maternal age is associated with a rapid decline in the production of
healthy and high-quality oocytes resulting in reduced fertility in women older than 35 years …

Abstract BACKGROUND Sirtuins (SIRT1-7) are a family of NAD+-dependent deacetylases
that catalyze post-translational modifications of proteins. Together, they respond to …

It has become a current social trend for women to delay childbearing. However, the quality of
oocytes from older females is compromised and the pregnancy rate of older women is lower …

Transition from maternal to embryonic transcriptional control is crucial for embryogenesis.
However, alternative splicing regulation during this process remains understudied. Using …

The female reproductive system is of great significance to women's health. Aging of the
female reproductive system occurs approximately 10 years prior to the natural age …

The aim of the present study was to address the effect of resveratrol-mediated upregulation
of sirtuin 1 (SIRT1) during oocyte maturation on mitochondrial function, the developmental …

Aging is a complex biological process that involves the accrual of bodily changes over a
long life span. In humans, advanced maternal age is associated with infertility and adverse …

Various morphological and cytological traits of oocytes and their surrounding cumulus cells
may be used to select oocytes for assisted reproduction. However, even with careful …

The present study assessed the effect of resveratrol on the expression of SIRT1 and
mitochondrial quality and quantity in porcine oocytes. Supplementing the maturation …

Background Ovarian function is closely related to the degree of vascular network
development surrounding the ovary. Maternal aging‐related construction defects in this …