Skeletal muscle is the largest tissue in the body and loss of its function or its regenerative
properties results in debilitating musculoskeletal disorders. Understanding the mechanisms …

Following their discovery in 1961, it was speculated that satellite cells were dormant
myoblasts, held in reserve until required for skeletal muscle repair. Evidence for this …

The muscle satellite cell was first described and actually named on the basis of its anatomic
location under the basement membrane surrounding each myofiber. For many years …

We have generated a mouse strain carrying a Cre-ERT2 knock-in allele at the Pax7 locus,
the Pax7CE allele (Lepper et al., 2009, Nature 460: 627–631). Combining Pax7CE and the …

Pax genes play key roles in the formation of tissues and organs during embryogenesis.
Pax3 and Pax7 mark myogenic progenitor cells and regulate their behavior and their entry …

Continuing research on the onset of skeletal myogenesis in the somite is providing new
insights into the behaviour of early myogenic progenitor cells and how signalling molecules …

Genetic regulatory networks governing skeletal myogenesis in the body are well
understood, yet their hierarchical relationships in the head remain unresolved. We show that …

Vertebrate muscle arises sequentially from embryonic, fetal, and adult myoblasts. Although
functionally distinct, it is unclear whether these myoblast classes develop from common or …

Adult skeletal muscle contains an abundant and highly accessible population of muscle
stem and progenitor cells called satellite cells. The primary function of satellite cells is to …

The outstanding regenerative capacity of skeletal muscle is attributed to the resident muscle
stem cell termed satellite cell. Satellite cells are essential for skeletal muscle regeneration as …