Selective autophagy is a quality control pathway through which cellular components are
sequestered into double-membrane vesicles and delivered to specific intracellular …

Autophagy-related (Atg) proteins are eukaryotic factors participating in various stages of the
autophagic process. Thus far 34 Atgs have been identified in yeast, including the key …

Mutations in valosin-containing protein (VCP) cause inclusion body myopathy (IBM), Paget's
disease of the bone, and frontotemporal dementia (IBMPFD). Patient muscle has …

SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) are now
generally accepted to be the major players in the final stage of the docking and the …

Autophagy is an evolutionarily-conserved catabolic process initiated by the engulfment of
cytosolic components in a crescent-shaped structure, called the phagophore, that expands …

▪ Abstract Golgi inheritance proceeds via sequential biogenesis and partitioning phases.
Although little is known about Golgi growth and replication (biogenesis), ultrastructural and …

Protein traffic is necessary to maintain homeostasis in all eukaryotic organisms. All newly
synthesized secretory proteins destined to the secretory and endolysosmal systems are …

Apg8 is a ubiquitin-like protein involved in autophagy in yeast. Apg8 is covalently but
transiently attached to membrane lipids through the actions of activating, conjugating, and …

Autophagy is a major degradation process of cytoplasmic components in eukaryotes, and
executes both bulk and selective degradation of targeted cargos. A set of autophagy-related …

NSF and p97 are ATPases required for the heterotypic fusion of transport vesicles with their
target membranes and the homotypic fusion of organelles. NSF uses ATP hydrolysis to …