Astrocytes are a group of glial cells that exhibit great morphological, transcriptional and
functional diversity both in the resting brain and in response to injury. In recent years …

Myelin, the membrane surrounding neuronal axons, is critical for central nervous system
(CNS) function. Injury to myelin-forming oligodendrocytes (OL) in chronic neurological …

Reactive astrocytes play critical roles in the occurrence of various neurological diseases
such as multiple sclerosis. Activation of astrocytes is often accompanied by a glycolysis …

Multiple sclerosis (MS) is characterized by a compromised blood-brain barrier (BBB)
resulting in central nervous system (CNS) entry of peripheral lymphocytes, including T cells …

Brain metastasis (BrM) is a major threat to the survival of melanoma, breast, and lung cancer
patients. Circulating tumor cells (CTCs) cross the blood-brain barrier (BBB) and sustain in …

A substantial body of evidence demonstrates an association between a malfunction in the
resolution of acute inflammation and the development of chronic inflammation. Recently, in …

Myelin antigen-reactive Th1 and Th17 cells are critical drivers of central nervous system
(CNS) autoimmune inflammation. Transcription factors T-bet and RORγt play a crucial role in …

Background Immune cells play crucial roles after spinal cord injury (SCI). However,
incomplete knowledge of immune contributions to injury and repair hinders development of …

Multiple sclerosis (MS) is a chronic disease characterized by inflammation and
neurodegeneration of the central nervous system. Despite the significant role of oxidative …

The neurodegenerative and inflammatory illnesses of amyotrophic lateral sclerosis and
multiple sclerosis were once thought to be completely distinct entities that did not share any …