For more than 25 years, it has been widely appreciated that Ca2+ influx is essential to
trigger T‐lymphocyte activation. Patch clamp analysis, molecular identification, and …

Shal-type (Kv4. x) K+ channels are expressed in a variety of tissue, with particularly high
levels in the brain and heart. These channels are the primary subunits that contribute to …

The somatodendritic subthreshold A-type K+ current (ISA) in nerve cells is a critical
component of the ensemble of voltage-gated ionic currents that determine somatodendritic …

The lymphocyte K+ channel Kv1. 3 constitutes an attractive pharmacological target for the
selective suppression of terminally differentiated effector memory T (TEM) cells in T cell …

The discovery of a diverse and unique set of ion channels in T lymphocytes has led to a
rapidly growing body of knowledge about their functional roles in the immune system. Here …

Potassium channels are tetrameric membrane proteins that selectively conduct K+ across
cellular membranes. With 78 family members, K+ channels make up about half of the …

After channel activation, and in some cases with sub-threshold depolarizing stimuli, Kv
channels undergo a time-dependent loss of conductivity by a family of mechanisms termed …

The selectivity filter of potassium channels is the structural element directly responsible for
the selective and rapid conduction of K+, whereas other parts of the protein are thought to …

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Kv1. 3 channels are involved in the switch to proliferation of normally quiescent cells, being
implicated in the control of cell cycle in many different cell types and in many different ways …