Integrins are considered the main cell-adhesion transmembrane receptors that play
multifaceted roles as extracellular matrix (ECM)-cytoskeletal linkers and transducers in …

Integrins, a group of heterodimer receptors for cell-matrix and cell-cell adhesion, mediate
various intracellular activities, including cell migration, polarity, survival, growth, and death …

Despite the high prognostic value of immune infiltrates in colorectal cancer (CRC),
metastatic disease remains resistant to immunotherapy by immune checkpoint blockade …

Melanoma brain metastases (MBM) variably respond to therapeutic interventions; thus
determining patient's prognosis. However, the mechanisms that govern therapy response …

The successful treatment of advanced colorectal cancer disease still represents an
insufficiently solved clinical challenge, which is further complicated by the fact that the …

The development of brain metastases hallmarks disease progression in 20–40% of
melanoma patients and is a serious obstacle to therapy. Understanding the processes …

Butyrate, a short-chain fatty acid, is predominantly produced by the decomposition of dietary
fiber in the colon. Recent studies have shown that sodium butyrate (NaB) can inhibit cell …

Resident memory T cells (T RM s) help control local immune homeostasis and contribute to
tissue-protective immune responses. The local cues that guide their differentiation and …

Background Extrachromosomal circular DNA (eccDNA) is omnipresent in cancers and
related to the progression of tumors and oncogene amplification. However, its function in …

Immunotherapy has emerged as the primary treatment modality for patients with advanced
Hepatocellular carcinoma (HCC). However, its clinical efficacy remains limited, benefiting …