[HTML][HTML] Genetic variation of hepatitis B virus and its significance for pathogenesis

ZH Zhang, CC Wu, XW Chen, X Li, J Li… - World journal of …, 2016 - ncbi.nlm.nih.gov
Hepatitis B virus (HBV) has a worldwide distribution and is endemic in many populations.
Due to its unique life cycle which requires an error-prone reverse transcriptase for …

Clinical impact of occult HBV infections

I Chemin, C Trepo - Journal of clinical virology, 2005 - Elsevier
HBV infection in the absence of HBsAg has been a matter of debate for years, but its
existence and clinical relevance are now supported by many publications, editorials and …

[HTML][HTML] Clinical significance of hepatitis B surface antigen mutants

N Coppola, L Onorato, C Minichini… - World journal of …, 2015 - ncbi.nlm.nih.gov
Hepatitis B virus (HBV) infection is a major public health problem in many countries, with
nearly 300 million people worldwide carrying HBV chronic infection and over 1 million …

[HTML][HTML] Paradoxical HBsAg and anti-HBs coexistence among chronic HBV infections: causes and consequences

X Jiang, L Chang, Y Yan, L Wang - International Journal of …, 2021 - ncbi.nlm.nih.gov
Hepatitis B surface antigen (HBsAg) and Hepatitis B surface antibody (anti-HBs) were
reported simultaneously among Hepatitis B virus (HBV) infections. HBsAg is a specific …

HBsAg variants: diagnostic-escape and diagnostic dilemma

SM Alavian, WF Carman, SM Jazayeri - Journal of Clinical virology, 2013 - Elsevier
A wide variety of commercial assays is available for the detection of hepatitis B surface
antigen (HBsAg). Clearly, the sensitivity of an assay to detect a variant is dependent on the …

[HTML][HTML] Clinical and virological significance of the co-existence of HBsAg and anti-HBs antibodies in hepatitis B chronic carriers

P Colson, P Borentain, A Motte, M Henry, V Moal… - Virology, 2007 - Elsevier
The co-existence of hepatitis B surface antigen (HBsAg) and anti-HBs antibodies (HBsAb) in
serum of hepatitis B virus (HBV)-chronic carriers has been previously associated with …

The amino acid residues at positions 120 to 123 are crucial for the antigenicity of hepatitis B surface antigen

Y Tian, Y Xu, Z Zhang, Z Meng, L Qin… - Journal of clinical …, 2007 - Am Soc Microbiol
The major hydrophilic region (MHR) of hepatitis B surface antigen (HBsAg) harbors
conformational B-cell epitopes and is the major target of neutralizing antibodies to HBsAg …

Biological significance of amino acid substitutions in hepatitis B surface antigen (HBsAg) for glycosylation, secretion, antigenicity and immunogenicity of HBsAg and …

C Wu, X Zhang, Y Tian, J Song… - Journal of General …, 2010 - microbiologyresearch.org
Amino acid substitutions of hepatitis B surface antigen (HBsAg) may affect the antigenicity
and immunogenicity of HBsAg, leading to immune escape and diagnostic failure. The amino …

Expression of hepatitis B virus genes in early embryonic cells originated from hamster ova and human spermatozoa transfected with the complete viral genome

BA Ali, TH Huang, HH Salem… - Asian Journal of …, 2006 - Wiley Online Library
Aim: To detect the expression of hepatitis B virus (HBV) genes (HB S and C genes) in early
embryonic cells after introducing motile human sperm carrying HBV DNA into zona‐free …

Investigation of a novel hepatitis B virus surface antigen (HBsAg) escape mutant affecting immunogenicity

MG Hossain, K Ueda - PLoS One, 2017 - journals.plos.org
Mutation in the hepatitis B virus surface antigen (HBsAg) may affect the efficiency of
diagnostic immunoassays or success of vaccinations using HBsAg. Thus, antigenicity and …