[HTML][HTML] Recent trends in synthetic enzymatic cascades promoted by alcohol dehydrogenases

G de Gonzalo, CE Paul - Current Opinion in Green and Sustainable …, 2021 - Elsevier
Alcohol dehydrogenases have fascinated chemists over the span of a few decades to
catalyze oxidation and reduction reactions and have been increasingly incorporated as …

Carbonic Anhydrase Variants Catalyze the Reduction of Dialkyl Ketones with High Enantioselectivity

R Chen, CS Kayrouz, E McAmis… - Angewandte Chemie …, 2024 - Wiley Online Library
Human carbonic anhydrase II (hCAII) naturally catalyzes the reaction between two achiral
molecules—water and carbon dioxide—to yield the achiral product carbonic acid through a …

Biocatalytic alkylation chemistry: Building molecular complexity with high selectivity

F Ospina, KH Schülke, SC Hammer - ChemPlusChem, 2022 - Wiley Online Library
Biocatalysis has traditionally been viewed as a field that primarily enables access to chiral
centers. This includes the synthesis of chiral alcohols, amines and carbonyl compounds …

Expanding the reactivity of flavin-dependent halogenases toward olefins via enantioselective intramolecular haloetherification and chemoenzymatic oxidative …

Y Jiang, D Mondal, JC Lewis - ACS catalysis, 2022 - ACS Publications
Of the different classes of halogenases characterized to date, flavin dependent halogenases
(FDHs) are most associated with site-selective halogenation of electron-rich arenes and …

Development of an Ene reductase-based biocatalytic process for the production of flavor compounds

A Papadopoulou, C Peters, S Borchert… - … Process Research & …, 2022 - ACS Publications
Ene reductases catalyze the biocatalytic reduction of activated alkenes, offering a powerful
biobased alternative to metal-catalyzed and organocatalyzed double-bond reductions. With …

Nature's Toolbox for the Hydrolysis of Lactams and Cyclic Imides

P Stockinger, R Buller - ACS Catalysis, 2024 - ACS Publications
Hydrolytic enzymes, such as lactamases or hydantoinases, can be valuably applied to
convert lactams (cyclic amides) and cyclic imides into optically pure compounds, for …

Effective engineering of a ketoreductase for the biocatalytic synthesis of an ipatasertib precursor

S Honda Malca, N Duss, J Meierhofer… - Communications …, 2024 - nature.com
Semi-rational enzyme engineering is a powerful method to develop industrial biocatalysts.
Profiting from advances in molecular biology and bioinformatics, semi-rational approaches …

Stereodivergent evolution of KpADH for the asymmetric reduction of diaryl ketones with para-substituents

J Zhang, J Zhou, G Xu, Y Ni - Molecular Catalysis, 2022 - Elsevier
KpADH is a promising biocatalyst for the synthesis of chiral bulky-bulky alcohols. Substrate
specificity toward diaryl ketone substrates with different substituents at phenyl group was …

Two Cascade Reactions with Oleate Hydratases for the Sustainable Biosynthesis of Fatty Acid-Derived Fine Chemicals

SA Prem, M Haack, F Melcher, M Ringel, D Garbe… - Catalysts, 2023 - mdpi.com
Oleate hydratases (OHs) are of significant industrial interest for the sustainable generation of
valuable fine chemicals. When combined with other enzymes in multi-step cascades, the …

A Collaborative Journey towards the Late‐Stage Functionalization of Added‐Value Chemicals Using Engineered Halogenases

J Büchler, E Hegarty, K Schroer… - Helvetica Chimica …, 2023 - Wiley Online Library
In 2017, two companies, Novartis AG and Syngenta AG, joined forces with the group of Prof.
Buller, head of the Competence Center for Biocatalysis (CCBIO), to tackle the challenge of …