Major depression is a leading contributor to the global burden of disease. This situation is
mainly related to the chronicity and/or recurrence of the disorder, and to poor response to …

The early life of most mammals is spent in close contact with the mother, and for the
neonate, early maternal separation is a traumatic event that, depending on various …

Recent studies have demonstrated a clear association between changes in the microbiota
and cognitive behavior. Intestinal dysbiosis, as modeled using GF mice (containing no …

In recent years, escitalopram (ESC) has been suggested to have different mechanisms of
action beyond its well known selective serotonin reuptake inhibition. The aim of this study is …

Cognitive disturbances are often reported as serious incapacitating symptoms by patients
suffering from major depressive disorders (MDDs). Such deficits have been observed in …

Early life stress (ELS) exerts long-lasting epigenetic influences on the brain and makes an
individual susceptible to later depression. It is poorly understood whether ELS and …

Bipolar disorder is characterized by recurrent manic and depressive episodes. Patients
suffering from this disorder experience dramatic mood swings with a wide variety of typical …

Adenosine A2A receptors (A2AR) are a sub-type of receptors enriched in basal ganglia,
activated by the neuromodulator adenosine, which interact with dopamine D2 receptors …

Major Depressive Disorder (MDD) is the most common psychiatric disease, affecting millions
of people worldwide. In addition to the well-defined depressive symptoms, patients suffering …

Early life stress is associated with long-term and pervasive adverse effects on
neuroendocrine development, affecting normal cognitive and emotional development …