The 1, 3-butadiene motif is widely found in many natural products and drug candidates with
relevant biological activities. Moreover, dienes are important targets for synthetic chemists …

The propargyl group is a highly versatile moiety whose introduction into small-molecule
building blocks opens up new synthetic pathways for further elaboration. The last decade …

Enantioselective propargylation and allenylation reactions pose an interesting challenge
because they require control of regioselectivity as well as enantioselectivity. This review …

The enantioselective silver-catalyzed propargylation of N-sulfonylketimines is described.
This reaction proceeds in high yield and excellent enantiomeric ratio and is compatible with …

The coagulation cascade is the process of the conversion of soluble fibrinogen to insoluble
fibrin that terminates in production of a clot. Factor Xa (FXa) is a serine protease involved in …

The addition of 2-bromobenzylmagnesium bromide to chiral N-tert-butanesulfinyl imines
derived from tetralone-type ketones proceeds with high levels of diastereocontrol. The …

The addition of an allenyl indium intermediate to chiral N-tert-butanesulfinyl imines 7
proceeds with high levels of diastereocontrol. The resulting homopropargylic amine …

The N‐propargylation of enantioenriched homopropargylic amine derivatives 3 proceeds in
high yields under basic conditions. The resulting 4‐azaocta‐1, 7‐dynes 5 were transformed …

Written by a" who is who" of leading organic chemists, this anniversary volume represent the
Organic Reactions editors' choice of the most important, ground-breaking and versatile …

The addition of propargylmagnesium bromide to fluorinated aromatic sulfinyl imines gave
homopropargyl amines with total regio-and diastereoselection. Complete reversal of …