Cell–cell junctions are specializations of the plasma membrane responsible for physically
integrating cells into tissues. We are now beginning to appreciate the diverse impacts that …

Considerable progress has been made in understanding the basic mechanisms that
regulate fluid and protein exchange across the endothelial and epithelial barriers of the lung …

Tissue mechanics drive morphogenesis, but how forces are sensed and transmitted to
control stem cell fate and self-organization remains unclear. We show that a …

The cytoplasm is the largest part of the cell by volume and hence its rheology sets the rate at
which cellular shape changes can occur. Recent experimental evidence suggests that …

One-cell-thick monolayers are the simplest tissues in multicellular organisms, yet they fulfill
critical roles in development and normal physiology. In early development, embryonic …

Secretion of pulmonary surfactant in the alveoli of the lungs is essential to maintain lung
function. Stretching of alveoli during lung inflation is the main trigger for surfactant secretion …

Epithelial monolayers are one-cell-thick tissue sheets that line most of the body surfaces,
separating internal and external environments. As part of their function, they must withstand …

It has been shown that mechanical ventilation in patients with, or at high-risk for, the
development of acute respiratory distress syndrome (ARDS) can be a double-edged sword …

The pulmonary alveolus, terminal gas-exchange unit of the lung, is composed of alveolar
epithelial and endothelial cells separated by a thin basement membrane and interstitial …

Lung fibrosis is increasingly detected with aging and has been associated with poor
outcomes in acute lung injury or infection. However, the molecular programs driving this pro …