An ecotoxicological view on neurotoxicity assessment
The numbers of potential neurotoxicants in the environment are raising and pose a great risk
for humans and the environment. Currently neurotoxicity assessment is mostly performed to …
for humans and the environment. Currently neurotoxicity assessment is mostly performed to …
Current Availability of Stem Cell-Based In Vitro Methods for Developmental Neurotoxicity (DNT) Testing
E Fritsche, M Barenys, J Klose… - Toxicological …, 2018 - academic.oup.com
There is evidence that chemical exposure during development can cause irreversible
impairments of the human developing nervous system. Therefore, testing compounds for …
impairments of the human developing nervous system. Therefore, testing compounds for …
Nrf2 pathway activation upon rotenone treatment in human iPSC-derived neural stem cells undergoing differentiation towards neurons and astrocytes
F Pistollato, D Canovas-Jorda, D Zagoura… - Neurochemistry …, 2017 - Elsevier
Activation of Nrf2/ARE signaling pathway occurs ubiquitously in most cell types upon
induction of oxidative stress. Rotenone, an inhibitor of mitochondrial complex I, can be used …
induction of oxidative stress. Rotenone, an inhibitor of mitochondrial complex I, can be used …
Methylglyoxal‐induced neurotoxic effects in primary neuronal‐like cells transdifferentiated from human mesenchymal stem cells: Impact of low concentrations
T Coccini, A Schicchi, CA Locatelli… - Journal of Applied …, 2023 - Wiley Online Library
In the last decades, advanced glycation end‐products (AGEs) have aroused the interest of
the scientific community due to the increasing evidence of their involvement in many …
the scientific community due to the increasing evidence of their involvement in many …
Developmental neurotoxicity screening for nanoparticles using neuron-like cells of human umbilical cord mesenchymal stem cells: example with magnetite …
T Coccini, P Pignatti, A Spinillo, U De Simone - Nanomaterials, 2020 - mdpi.com
Metallic nanoparticles (NPs), as iron oxide NPs, accumulate in organs, cross the blood-brain
barrier and placenta, and have the potential to elicit developmental neurotoxicity (DNT) …
barrier and placenta, and have the potential to elicit developmental neurotoxicity (DNT) …
Modelling neurological diseases in large animals: Criteria for model selection and clinical assessment
SL Eaton, F Murdoch, NM Rzechorzek, G Thompson… - Cells, 2022 - mdpi.com
Issue: The impact of neurological disorders is recognised globally, with one in six people
affected in their lifetime and few treatments to slow or halt disease progression. This is due …
affected in their lifetime and few treatments to slow or halt disease progression. This is due …
Human Umbilical Cord Mesenchymal Stem Cell–Based in vitro Model for Neurotoxicity Testing
T Coccini, A Spinillo, M Roccio, E Lenta… - Current …, 2022 - Wiley Online Library
Neurotoxicity (NT) testing for regulatory purposes is based on in vivo animal testing. There is
general consensus, however, about the need for the development of alternative …
general consensus, however, about the need for the development of alternative …
Application of human pluripotent stem cells and pluripotent stem cell-derived cellular models for assessing drug toxicity
Introduction: Human pluripotent stem cells (hPSCs) are capable of differentiating into all
types of cells in the body and so provide suitable toxicology screening systems even for hard …
types of cells in the body and so provide suitable toxicology screening systems even for hard …
Pluripotent stem cells for target organ developmental toxicity testing
X Wu, Y Chen, A Kreutz, B Silver… - Toxicological …, 2024 - academic.oup.com
Prenatal developmental toxicity research focuses on understanding the potential adverse
effects of environmental agents, drugs, and chemicals on the development of embryos and …
effects of environmental agents, drugs, and chemicals on the development of embryos and …
Development of in vitro toxicology: a historic story
S Singh, VK Khanna, AB Pant - In vitro toxicology, 2018 - Elsevier
Toxicology plays a pivotal role in driving global research and medicine. The complete
understanding of this science is definitely needed for human welfare and cure. In vitro …
understanding of this science is definitely needed for human welfare and cure. In vitro …