The numbers of potential neurotoxicants in the environment are raising and pose a great risk
for humans and the environment. Currently neurotoxicity assessment is mostly performed to …

There is evidence that chemical exposure during development can cause irreversible
impairments of the human developing nervous system. Therefore, testing compounds for …

Activation of Nrf2/ARE signaling pathway occurs ubiquitously in most cell types upon
induction of oxidative stress. Rotenone, an inhibitor of mitochondrial complex I, can be used …

In the last decades, advanced glycation end‐products (AGEs) have aroused the interest of
the scientific community due to the increasing evidence of their involvement in many …

Metallic nanoparticles (NPs), as iron oxide NPs, accumulate in organs, cross the blood-brain
barrier and placenta, and have the potential to elicit developmental neurotoxicity (DNT) …

Issue: The impact of neurological disorders is recognised globally, with one in six people
affected in their lifetime and few treatments to slow or halt disease progression. This is due …

Neurotoxicity (NT) testing for regulatory purposes is based on in vivo animal testing. There is
general consensus, however, about the need for the development of alternative …

Introduction: Human pluripotent stem cells (hPSCs) are capable of differentiating into all
types of cells in the body and so provide suitable toxicology screening systems even for hard …

Prenatal developmental toxicity research focuses on understanding the potential adverse
effects of environmental agents, drugs, and chemicals on the development of embryos and …

Toxicology plays a pivotal role in driving global research and medicine. The complete
understanding of this science is definitely needed for human welfare and cure. In vitro …