Deformed wing virus (DWV; Iflaviridae) is one of many viruses infecting honeybees and one
of the most heavily investigated due to its close association with honeybee colony collapse …

Bioinformatic analysis can not only accelerate drug target identification and drug candidate
screening and refinement, but also facilitate characterization of side effects and predict drug …

Severe acute respiratory syndrome coronavirus nsp1 protein suppresses host gene
expression, including type I interferon production, by promoting host mRNA degradation and …

Acute bee paralysis virus (ABPV), Kashmir bee virus (KBV) and Israeli acute paralysis virus
(IAPV) are part of a complex of closely related viruses from the Family Dicistroviridae. These …

As obligate intracellular parasites, virus reproduction requires host cell functions. Despite
variations in genome size and configuration, nucleic acid composition, and their repertoire of …

How pseudouridylation (Ψ), the most common and evolutionarily conserved modification of
rRNA, regulates ribosome activity is poorly understood. Medically, Ψ is important because …

In eukaryotes, protein synthesis initiates primarily by a mechanism that requires a modified
nucleotide 'cap'on the mRNA and also proteins that recruit and position the ribosome. Many …

To ensure efficient propagation, viruses need to rapidly produce viral proteins after cell
entrance. Since viral genomes do not encode any components of the protein biosynthesis …

Fighting viral infections is hampered by the scarcity of viral targets and their variability,
resulting in development of resistance. Viruses depend on cellular molecules—which are …

Although studies on viral gene expression were essential for the discovery of internal
ribosome entry sites (IRESs), it is becoming increasingly clear that IRES activities are …