Pyrazole and its derivatives are considered a pharmacologically important active scaffold
that possesses almost all types of pharmacological activities. The presence of this nucleus in …

Pyrazole is a five-membered aromatic heterocyclic ring with two adjacent nitrogen atoms C 3
H 3 N 2 H. The presence of this nucleus in pharmacological agents of various therapeutic …

Pyrazole, a five membered heteroaromatic ring with two nitrogen atoms is of immense
significance. Presence of this nucleus in the pharmacological agents of diverse therapeutic …

Azepane-based compounds showed a variety of pharmacological properties, and its
derivatives possess a high degree of structural diversity, and it is useful for the discovery of …

In this study, a new series of quinazolinone-pyrazole hybrids were designed, synthesized
and screened for their α-glucosidase inhibitory activity. The results of the in vitro screening …

In an attempt to find potential anticancer agents, a series of novel ethyl 4-(3-(aryl)-1-phenyl-
1H-pyrazol-4-yl)-2-oxo-6-(pyridin-3-yl) cyclohex-3-enecarboxylates 5a-i and 5-(3-(4 …

Drug–drug interaction (DDI) defines a situation in which one drug affects the activity of
another when both are administered together. DDI is a common cause of adverse drug …

Polymerization of tubulin dimers to form microtubules is one of the key events in cell
proliferation. The inhibition of this event has long been recognized as a potential treatment …

Abstract A strategy for the 1, 3-dipolar cycloaddition of nitrilimines to δ-allenoates has been
developed to provide various 1, 3, 5-trisubstituted pyrazole-4-carboxylates and pyrazole-4 …

1, 3‐Diphenylpyrazole‐4‐carboxylaldehyde and o‐hydroxyacetophenone were exploited as
starting materials for the synthesis of novel substituted chalconated pyrazole derivative. The …