Breast cancer (BC) is one of the most common cancers among women; genetic mutations
reflect the development of this disease. Mutations in cell signaling factors can be the main …

Pathogenic variants (PVs) in multiple genes are known to increase the risk of early-onset
renal cancer (eoRC). However, many eoRC patients lack PVs in RC-specific genes; thus …

Nowadays CHK2 mutation is studied frequently in hereditary breast and ovarian cancer
patients in addition to BRCA1/BRCA2. CHK2 is a tumor suppressor gene that encodes a …

Study on the Mechanism of Cell Cycle Checkpoint Kinase 2 (CHEK2) Gene Dysfunction in
Chemotherapeutic Drug Resistance of Triple Negative Breast Cancer Cells - PMC Back to …

Introduction: CHEK2 (Checkpoint kinase 2) germline mutations were associated with an
elevated risk of breast cancer, colorectal cancer, and other familiar cancers. Loss-of-function …

Purpose Because many countries lack the capacity to follow the international guidelines for
genetic testing, we suggest the specific approach for establishing local genetic testing …

Abstract Introduction: The TP53 and CHEK2 genes have been described as breast cancer
susceptibility genes and some of their polymorphisms have been associated with an …

为了使乳腺X 射线摄影在乳腺癌筛查中的应用达到最优化, 本文回顾性分析了在我院行乳腺X
射线摄影和乳腺彩色多普勒超声检查, 并取得病理结果的患者共132 人, 139 个病灶 …

Purpose Individual genetic background can play an essential role in determining the
development of esophageal squamous cell carcinoma (ESCC). PTPN13 and CHEK2 play …

Adrenocortical carcinoma (ACC) is an aggressive form of cancer that originates in the cortex
of the adrenal gland; the incidence of ACC is 1.5 to 2 cases per million people per year …