Biocatalysis has become an important aspect of modern organic synthesis, both in
academia and across the chemical and pharmaceutical industries. Its success has been …

Enzymes are versatile catalysts and their synthetic potential has been recognized for a long
time. In order to exploit their full potential, enzymes often need to be re-engineered or …

Simple Summary The most recent intergovernmental panel on climate change (IPCC 2021)
has shown that the human influence on climate change has been unprecedented, predicting …

A variety of chemicals have been produced through metabolic engineering approaches, and
enhancing biosynthesis performance can be achieved by using enzymes with high catalytic …

Metagenomics and directed evolution technology have brought a revolution in search of
novel enzymes from extreme environment and improvement of existing enzymes and tuning …

Chitin is abundant in nature and its degradation products are highly valuable for numerous
applications. Thermophilic chitinases are increasingly appreciated for their capacity to …

Soil microorganisms historically have been a rich resource for natural product discovery, yet
the majority of these microbes remain uncultivated and their biosynthetic capacity is left …

Glycans that coat the surface of bacteria are compelling antibiotic targets because they
contain distinct monosaccharides that are linked to pathogenesis and are absent in human …

The vast majority of glycosidases characterized to date follow one of the variations of the
'Koshland'mechanisms to hydrolyse glycosidic bonds through substitution reactions. Here …

Carbohydrate-active enzymes (CAZymes) are responsible for the biosynthesis, modification
and degradation of all glycans in Nature. Advances in genomic and metagenomic …