[HTML][HTML] Biocatalysis
Biocatalysis has become an important aspect of modern organic synthesis, both in
academia and across the chemical and pharmaceutical industries. Its success has been …
academia and across the chemical and pharmaceutical industries. Its success has been …
Advances in ultrahigh-throughput screening for directed enzyme evolution
U Markel, KD Essani, V Besirlioglu, J Schiffels… - Chemical Society …, 2020 - pubs.rsc.org
Enzymes are versatile catalysts and their synthetic potential has been recognized for a long
time. In order to exploit their full potential, enzymes often need to be re-engineered or …
time. In order to exploit their full potential, enzymes often need to be re-engineered or …
[HTML][HTML] Challenges of biomass utilization for bioenergy in a climate change scenario
Simple Summary The most recent intergovernmental panel on climate change (IPCC 2021)
has shown that the human influence on climate change has been unprecedented, predicting …
has shown that the human influence on climate change has been unprecedented, predicting …
Biosensor-guided discovery and engineering of metabolic enzymes
A variety of chemicals have been produced through metabolic engineering approaches, and
enhancing biosynthesis performance can be achieved by using enzymes with high catalytic …
enhancing biosynthesis performance can be achieved by using enzymes with high catalytic …
Molecular biology interventions for activity improvement and production of industrial enzymes
Metagenomics and directed evolution technology have brought a revolution in search of
novel enzymes from extreme environment and improvement of existing enzymes and tuning …
novel enzymes from extreme environment and improvement of existing enzymes and tuning …
[HTML][HTML] A novel thermophilic chitinase directly mined from the marine metagenome using the deep learning tool Preoptem
Y Zhang, F Guan, G Xu, X Liu, Y Zhang, J Sun… - Bioresources and …, 2022 - Springer
Chitin is abundant in nature and its degradation products are highly valuable for numerous
applications. Thermophilic chitinases are increasingly appreciated for their capacity to …
applications. Thermophilic chitinases are increasingly appreciated for their capacity to …
[HTML][HTML] Discovery of novel biosynthetic gene cluster diversity from a soil metagenomic library
ALR Santana-Pereira, M Sandoval-Powers… - Frontiers in …, 2020 - frontiersin.org
Soil microorganisms historically have been a rich resource for natural product discovery, yet
the majority of these microbes remain uncultivated and their biosynthetic capacity is left …
the majority of these microbes remain uncultivated and their biosynthetic capacity is left …
Thioglycosides act as metabolic inhibitors of bacterial glycan biosynthesis
IL Quintana, A Paul, A Chowdhury… - ACS Infectious …, 2023 - ACS Publications
Glycans that coat the surface of bacteria are compelling antibiotic targets because they
contain distinct monosaccharides that are linked to pathogenesis and are absent in human …
contain distinct monosaccharides that are linked to pathogenesis and are absent in human …
An alternative broad-specificity pathway for glycan breakdown in bacteria
SA Nasseri, AC Lazarski, IL Lemmer, CY Zhang… - Nature, 2024 - nature.com
The vast majority of glycosidases characterized to date follow one of the variations of the
'Koshland'mechanisms to hydrolyse glycosidic bonds through substitution reactions. Here …
'Koshland'mechanisms to hydrolyse glycosidic bonds through substitution reactions. Here …
[HTML][HTML] Advances in the understanding and exploitation of carbohydrate-active enzymes
RK Bains, SA Nasseri, JF Wardman… - Current Opinion in …, 2024 - Elsevier
Carbohydrate-active enzymes (CAZymes) are responsible for the biosynthesis, modification
and degradation of all glycans in Nature. Advances in genomic and metagenomic …
and degradation of all glycans in Nature. Advances in genomic and metagenomic …