Sperm DNA integrity is crucial for fertilization and development of healthy offspring. The
spermatozoon undergoes extensive molecular remodeling of its nucleus during later phases …

Reactive oxygen species (ROS) have been extensively studied as a cause of male infertility.
Excessive levels of ROS coupled with a deficiency in antioxidants can lead to oxidative …

Although mitochondria are best known for being the eukaryotic cell powerhouses, these
organelles participate in various cellular functions besides ATP production, such as calcium …

The male factor is considered a major contributory factor to infertility. Apart from the
conventional causes for male infertility such as varicocoele, cryptorchidism, infections …

Sperm DNA integrity is essential for the accurate transmission of genetic information. It has a
highly compact and complex structure and is capable of decondensation—features that must …

Spermatogenesis is a complex process of proliferation and differentiation during male germ
cell development involving mitosis, meiosis and spermiogenesis. Endogenous and …

BACKGROUND In natural conception only a few sperm cells reach the ampulla or the site of
fertilization. This population is a selected group of cells since only motile cells can pass …

Current treatments of subfertile couples are usually empiric, as the true cause of subfertility
often remains unknown. Therefore, we outline the role of nutritional and biochemical factors …

DNA damage in the male germ line has been associated with poor semen quality, low
fertilization rates, impaired preimplantation development, increased abortion and an …

BACKGROUND The human sperm cell is very well suited for proteomic studies, as it is
accessible, can be easily purified and is believed to be transcriptionally and translationally …