A review on recent approaches on molecular docking studies of novel compounds targeting acetylcholinesterase in Alzheimer disease
SC Peitzika, E Pontiki - Molecules, 2023 - mdpi.com
Alzheimer's disease (AD), a neurodegenerative brain disorder that affects millions of people
worldwide, is characterized by memory loss and cognitive decline. Low levels of …
worldwide, is characterized by memory loss and cognitive decline. Low levels of …
4‐Hydroxycoumarin: A versatile substrate for transition‐metal‐free multicomponent synthesis of bioactive heterocycles
B Borah, K Dhar Dwivedi… - Asian Journal of Organic …, 2021 - Wiley Online Library
One‐pot multi‐component reactions especially under transition‐metal‐free catalysis served
as an efficient, and environmentally friendly method for the construction of value‐added …
as an efficient, and environmentally friendly method for the construction of value‐added …
NRF2 activation by nitrogen heterocycles: a review
Several nitrogen heterocyclic analogues have been applied to clinical practice, and about
75% of drugs approved by the FDA contain at least a heterocyclic moiety. Thus, nitrogen …
75% of drugs approved by the FDA contain at least a heterocyclic moiety. Thus, nitrogen …
Synthesis of N‐alkylated pyrazolo[3,4‐d]pyrimidine analogs and evaluation of acetylcholinesterase and carbonic anhydrase inhibition properties
Abstract Fused pyrimidines, especially pyrazolo [3, 4‐d] pyrimidines, are among the most
preferred building blocks for pharmacology studies, as they exhibit a broad spectrum of …
preferred building blocks for pharmacology studies, as they exhibit a broad spectrum of …
Eco-friendly synthesis of pyrimidines and its derivatives: A review on broad spectrum bioactive moiety with huge therapeutic profile
Among all heterocyclic compounds, pyrimidine is of prime interest, exhibit broad spectrum of
biological activities, because of its occurrence in deoxyribonucleic acid bases. The bioactive …
biological activities, because of its occurrence in deoxyribonucleic acid bases. The bioactive …
FeCl3-assisted niobium-catalyzed cycloaddition of nitriles and alkynes: synthesis of alkyl-and arylpyrimidines based on independent functions of NbCl5 and FeCl3 …
M Fuji, Y Obora - Organic letters, 2017 - ACS Publications
NbCl5-catalyzed [2+ 2+ 2] cycloaddition of nitriles with alkynes was used to synthesize
pyrimidine derivatives. In this reaction, the use of individual Lewis acids, namely NbCl5 and …
pyrimidine derivatives. In this reaction, the use of individual Lewis acids, namely NbCl5 and …
Acefylline Derivatives as a New Class of Anticancer Agents: Synthesis, Molecular Docking, and Anticancer, Hemolytic, and Thrombolytic Activities of Acefylline …
The synthesis of novel acefyllines and exploring their biological activities attract researchers
due to their medicinal applications. Therefore, the current work reports the successful …
due to their medicinal applications. Therefore, the current work reports the successful …
[PDF][PDF] Antioxidant Potential of Pyrimidine Derivatives against Oxidative Stress.
N Nair, J Majeed, PK Pandey, R Sweety… - Indian Journal of …, 2022 - researchgate.net
The human body is under constant attack from oxidative stress which in turn induces the
excessive production of free radicals, particularly the reactive oxygen species in the body …
excessive production of free radicals, particularly the reactive oxygen species in the body …
[PDF][PDF] Synthesis, characterization and study biological activity of some new pyrimidine and 1, 2, 3, 4-tetrazole derivatives based on sulfadiazine
AF Abbass, EH Zimam - International Journal of ChemTech …, 2016 - researchgate.net
New 1, 2, 3, 4-Tetrazole derivatives [S1a-S5c] were prepared by 1, 3-diolarcyclo addition
reaction of compound [2-azido-N-(4-(N-(pyrimidin-2-yl) sulfamoyl) phenyl) acetamide] with …
reaction of compound [2-azido-N-(4-(N-(pyrimidin-2-yl) sulfamoyl) phenyl) acetamide] with …
Anticancer Biological Profile of Some Heterocylic Moieties-Thiadiazole, Benzimidazole, Quinazoline, and Pyrimidine
PS Sidat, TMK Jaber, SR Vekariya… - …, 2022 - pharmacophorejournal.com
Cancer is a disease characterized by genetic or epigenetic alterations in somatic cells that
result in uncontrolled cell growth and spread to other regions of the body. They are one type …
result in uncontrolled cell growth and spread to other regions of the body. They are one type …