Alzheimer's disease (AD), a neurodegenerative brain disorder that affects millions of people
worldwide, is characterized by memory loss and cognitive decline. Low levels of …

One‐pot multi‐component reactions especially under transition‐metal‐free catalysis served
as an efficient, and environmentally friendly method for the construction of value‐added …

Several nitrogen heterocyclic analogues have been applied to clinical practice, and about
75% of drugs approved by the FDA contain at least a heterocyclic moiety. Thus, nitrogen …

Abstract Fused pyrimidines, especially pyrazolo [3, 4‐d] pyrimidines, are among the most
preferred building blocks for pharmacology studies, as they exhibit a broad spectrum of …

Among all heterocyclic compounds, pyrimidine is of prime interest, exhibit broad spectrum of
biological activities, because of its occurrence in deoxyribonucleic acid bases. The bioactive …

NbCl5-catalyzed [2+ 2+ 2] cycloaddition of nitriles with alkynes was used to synthesize
pyrimidine derivatives. In this reaction, the use of individual Lewis acids, namely NbCl5 and …

The synthesis of novel acefyllines and exploring their biological activities attract researchers
due to their medicinal applications. Therefore, the current work reports the successful …

The human body is under constant attack from oxidative stress which in turn induces the
excessive production of free radicals, particularly the reactive oxygen species in the body …

New 1, 2, 3, 4-Tetrazole derivatives [S1a-S5c] were prepared by 1, 3-diolarcyclo addition
reaction of compound [2-azido-N-(4-(N-(pyrimidin-2-yl) sulfamoyl) phenyl) acetamide] with …

Cancer is a disease characterized by genetic or epigenetic alterations in somatic cells that
result in uncontrolled cell growth and spread to other regions of the body. They are one type …