Allosteric control of mammalian DNA methyltransferases–a new regulatory paradigm
A Jeltsch, RZ Jurkowska - Nucleic acids research, 2016 - academic.oup.com
In mammals, DNA methylation is introduced by the DNMT1, DNMT3A and DNMT3B
methyltransferases, which are all large multi-domain proteins containing a catalytic C …
methyltransferases, which are all large multi-domain proteins containing a catalytic C …
Biochemistry and biology of mammalian DNA methyltransferases
DNA methylation is a stable but not irreversible epigenetic signal that silences gene
expression. It has a variety of important functions in mammals, including control of gene …
expression. It has a variety of important functions in mammals, including control of gene …
The Dnmt1 DNA-(cytosine-C5)-methyltransferase methylates DNA processively with high preference for hemimethylated target sites
A Hermann, R Goyal, A Jeltsch - Journal of Biological Chemistry, 2004 - ASBMB
In the cell, Dnmt1 is the major enzyme in maintenance of the pattern of DNA methylation
after DNA replication. Evidence suggests that the protein is located at the replication fork …
after DNA replication. Evidence suggests that the protein is located at the replication fork …
Reprogrammable CRISPR/Cas9-based system for inducing site-specific DNA methylation
Advances in sequencing technology allow researchers to map genome-wide changes in
DNA methylation in development and disease. However, there is a lack of experimental …
DNA methylation in development and disease. However, there is a lack of experimental …
Mammalian DNA methyltransferases: a structural perspective
X Cheng, RM Blumenthal - Structure, 2008 - cell.com
The methylation of mammalian DNA, primarily at CpG dinucleotides, has long been
recognized to play a major role in controlling gene expression, among other functions. Given …
recognized to play a major role in controlling gene expression, among other functions. Given …
5-Aza-deoxycytidine induces selective degradation of DNA methyltransferase 1 by a proteasomal pathway that requires the KEN box, bromo-adjacent homology …
K Ghoshal, J Datta, S Majumder, S Bai… - … and cellular biology, 2005 - Am Soc Microbiol
Azacytidine-and 5-aza-deoxycytidine (5-aza-CdR)-mediated reactivation of tumor
suppressor genes silenced by promoter methylation has provided an alternate approach in …
suppressor genes silenced by promoter methylation has provided an alternate approach in …
Mechanism of stimulation of catalytic activity of Dnmt3A and Dnmt3B DNA-(cytosine-C5)-methyltransferases by Dnmt3L
Dnmt3L has been identified as a stimulator of the catalytic activity of de novo DNA
methyltransferases. It is essential in the development of germ cells in mammals. We show …
methyltransferases. It is essential in the development of germ cells in mammals. We show …
Repeat‐induced point mutation and other genome defense mechanisms in fungi
E Gladyshev - The fungal kingdom, 2017 - Wiley Online Library
Mobile DNA, comprising both active and decaying copies of transposable elements (TEs), is
present in nearly all living organisms. Although fungal genomes tend to be significantly …
present in nearly all living organisms. Although fungal genomes tend to be significantly …
Base editor scanning charts the DNMT3A activity landscape
DNA methylation is critical for regulating gene expression, necessitating its accurate
placement by enzymes such as the DNA methyltransferase DNMT3A. Dysregulation of this …
placement by enzymes such as the DNA methyltransferase DNMT3A. Dysregulation of this …
The DNMT3 family of mammalian de novo DNA methyltransferases
F Chédin - Progress in molecular biology and translational …, 2011 - Elsevier
The deposition of DNA methylation at promoters of transposons, X-linked genes, imprinted
genes, and other lineage-specific genes is clearly associated with long-term transcriptional …
genes, and other lineage-specific genes is clearly associated with long-term transcriptional …