Extracting physical chemistry from mechanics: a new approach to investigate DNA interactions with drugs and proteins in single molecule experiments
MS Rocha - Integrative Biology, 2015 - academic.oup.com
In this review we focus on the idea of establishing connections between the mechanical
properties of DNA–ligand complexes and the physical chemistry of DNA–ligand interactions …
properties of DNA–ligand complexes and the physical chemistry of DNA–ligand interactions …
DNA‐doxorubicin interaction: New insights and peculiarities
We have investigated the interaction of the DNA molecule with the anticancer drug
doxorubicin (doxo) by using three different experimental techniques: single molecule …
doxorubicin (doxo) by using three different experimental techniques: single molecule …
The mismatch repair endonuclease MutLα tethers duplex regions of DNA together and relieves DNA torsional tension
SJ Witte, IM Rosa, BW Collingwood… - Nucleic Acids …, 2023 - academic.oup.com
In eukaryotic mismatch repair, MutS homologs recognize mismatches and recruit the MutLα
endonuclease which introduces a nick in the newly replicated, error-containing DNA strand …
endonuclease which introduces a nick in the newly replicated, error-containing DNA strand …
Single molecule high-throughput footprinting of small and large DNA ligands
M Manosas, J Camunas-Soler, V Croquette… - Nature …, 2017 - nature.com
Most DNA processes are governed by molecular interactions that take place in a sequence-
specific manner. Determining the sequence selectivity of DNA ligands is still a challenge …
specific manner. Determining the sequence selectivity of DNA ligands is still a challenge …
Modulating the chemo-mechanical response of structured DNA assemblies through binding molecules
Recent advances in DNA nanotechnology led the fabrication and utilization of various DNA
assemblies, but the development of a method to control their global shapes and mechanical …
assemblies, but the development of a method to control their global shapes and mechanical …
New insights into the mechanism of action of the drug chloroquine: direct interaction with DNA and cytotoxicity
EA Costa, AP Gonçalves, JAD Batista… - The Journal of …, 2022 - ACS Publications
Chloroquine (CLQ) and hydroxychloroquine (HCLQ) are compounds largely employed in
the treatment of various human diseases for decades. Nevertheless, a number of intrinsic …
the treatment of various human diseases for decades. Nevertheless, a number of intrinsic …
Hydroxychloroquine exhibits a strong complex interaction with DNA: unraveling the mechanism of action
In the past months, the use of the drug hydroxychloroquine has considerably increased in
many countries, associated with a proposed treatment for the COVID-19 disease. Although …
many countries, associated with a proposed treatment for the COVID-19 disease. Although …
Freezing shortens the lifetime of DNA molecules under tension
WJ Chung, Y Cui, CS Chen, WH Wei… - Journal of biological …, 2017 - Springer
DNA samples are commonly frozen for storage. However, freezing can compromise the
integrity of DNA molecules. Considering the wide applications of DNA molecules in …
integrity of DNA molecules. Considering the wide applications of DNA molecules in …
Conformation and dynamics of long-chain end-tethered polymers in microchannels
Polyelectrolytes constitute an important group of materials, used for such different purposes
as the stabilization of emulsions and suspensions or oil recovery. They are also studied and …
as the stabilization of emulsions and suspensions or oil recovery. They are also studied and …