Extracting physical chemistry from mechanics: a new approach to investigate DNA interactions with drugs and proteins in single molecule experiments

MS Rocha - Integrative Biology, 2015 - academic.oup.com
In this review we focus on the idea of establishing connections between the mechanical
properties of DNA–ligand complexes and the physical chemistry of DNA–ligand interactions …

DNA‐doxorubicin interaction: New insights and peculiarities

EF Silva, RF Bazoni, EB Ramos, MS Rocha - Biopolymers, 2017 - Wiley Online Library
We have investigated the interaction of the DNA molecule with the anticancer drug
doxorubicin (doxo) by using three different experimental techniques: single molecule …

The mismatch repair endonuclease MutLα tethers duplex regions of DNA together and relieves DNA torsional tension

SJ Witte, IM Rosa, BW Collingwood… - Nucleic Acids …, 2023 - academic.oup.com
In eukaryotic mismatch repair, MutS homologs recognize mismatches and recruit the MutLα
endonuclease which introduces a nick in the newly replicated, error-containing DNA strand …

Single molecule high-throughput footprinting of small and large DNA ligands

M Manosas, J Camunas-Soler, V Croquette… - Nature …, 2017 - nature.com
Most DNA processes are governed by molecular interactions that take place in a sequence-
specific manner. Determining the sequence selectivity of DNA ligands is still a challenge …

Nanomanipulation in biomedical applications

C Hou, D Sun, L Dong - Current Robotics Reports, 2021 - Springer
Abstract Purpose of Review Progress in nanorobotics over the past decades has
dramatically extended our ability to explore the world down to individual molecules/atoms …

Modulating the chemo-mechanical response of structured DNA assemblies through binding molecules

C Lee, YJ Kim, KS Kim, JY Lee… - Nucleic acids research, 2021 - academic.oup.com
Recent advances in DNA nanotechnology led the fabrication and utilization of various DNA
assemblies, but the development of a method to control their global shapes and mechanical …

New insights into the mechanism of action of the drug chloroquine: direct interaction with DNA and cytotoxicity

EA Costa, AP Gonçalves, JAD Batista… - The Journal of …, 2022 - ACS Publications
Chloroquine (CLQ) and hydroxychloroquine (HCLQ) are compounds largely employed in
the treatment of various human diseases for decades. Nevertheless, a number of intrinsic …

Hydroxychloroquine exhibits a strong complex interaction with DNA: unraveling the mechanism of action

RF Bazoni, TA Moura, MS Rocha - The Journal of Physical …, 2020 - ACS Publications
In the past months, the use of the drug hydroxychloroquine has considerably increased in
many countries, associated with a proposed treatment for the COVID-19 disease. Although …

Freezing shortens the lifetime of DNA molecules under tension

WJ Chung, Y Cui, CS Chen, WH Wei… - Journal of biological …, 2017 - Springer
DNA samples are commonly frozen for storage. However, freezing can compromise the
integrity of DNA molecules. Considering the wide applications of DNA molecules in …

Conformation and dynamics of long-chain end-tethered polymers in microchannels

T Roy, K Szuttor, J Smiatek, C Holm, S Hardt - Polymers, 2019 - mdpi.com
Polyelectrolytes constitute an important group of materials, used for such different purposes
as the stabilization of emulsions and suspensions or oil recovery. They are also studied and …