[HTML][HTML] Making the final cut: pathogenic amyloid-β peptide generation by γ-secretase
H Steiner, A Fukumori, S Tagami, M Okochi - Cell Stress, 2018 - ncbi.nlm.nih.gov
Alzheimers disease (AD) is a devastating neurodegenerative disease of the elderly
population. Genetic evidence strongly suggests that aberrant generation and/or clearance of …
population. Genetic evidence strongly suggests that aberrant generation and/or clearance of …
The genomic architecture of hidradenitis suppurativa—a systematic review
Hidradenitis suppurativa is a chronic, suppurative condition of the pilosebaceous unit
manifesting as painful nodules, abscesses, and sinus tracts mostly in, but not limited to …
manifesting as painful nodules, abscesses, and sinus tracts mostly in, but not limited to …
Cryo-EM structures of human γ-secretase
Highlights•Methods on sample preparation and electron microscopy of human γ-
secretase.•A summary of cryo-EM structures of human γ-secretase.•Functional insights …
secretase.•A summary of cryo-EM structures of human γ-secretase.•Functional insights …
Negative evidence for a role of APH1B T27I variant in Alzheimer's disease
Abstract γ-secretase is a macromolecular complex that catalyzes intramembranous
hydrolysis of more than 100 membrane-bound substrates. The complex is composed of …
hydrolysis of more than 100 membrane-bound substrates. The complex is composed of …
High-efficient production and biophysical characterisation of nicastrin and its interaction with APPC100
K Yu, G Yang, J Labahn - Scientific reports, 2017 - nature.com
Nicastrin, the largest member among the four components of the γ-secretase complex, has
been identified to be the substrate recognizer for the proteolytic activity of the complex. Here …
been identified to be the substrate recognizer for the proteolytic activity of the complex. Here …
Structural biology of Notch signaling
KL Arnett, TCM Seegar, SC Blacklow - … Notch in Cancer: From the Fruit Fly …, 2018 - Springer
The conserved Notch signaling pathway plays a central role in development and adult tissue
homeostasis. Notch signaling is initiated by binding to a transmembrane ligand. E3 ubiquitin …
homeostasis. Notch signaling is initiated by binding to a transmembrane ligand. E3 ubiquitin …
[PDF][PDF] Characterization of the subunits of the γ-secretase complex.
K Yu - 2016 - docserv.uni-duesseldorf.de
The Alzheimer's disease (AD) is an irreversible, progressive, neurodegenerative brain
disease. It was named after a German psychiatrist Alois Alzheimer who described the first …
disease. It was named after a German psychiatrist Alois Alzheimer who described the first …