The integrated stress response (ISR) is a highly conserved biochemical pathway involved in
maintaining proteostasis and cell health in the face of diverse stressors. In this Review, we …

The integrated stress response (ISR) is a highly conserved biochemical pathway that
regulates protein synthesis. The ISR is activated in response to diverse stressors to restore …

Cells respond to intrinsic and extrinsic stresses by reducing global protein synthesis and
activating gene programs necessary for survival. Here, we show that the integrated stress …

During their quest for growth, adaptation, and survival, cancer cells create a favorable
environment through the manipulation of normal cellular mechanisms. They increase …

Significance: Stress granules (SGs) are biomolecular condensates that form upon global
translation suppression during stress. SGs are enriched in translation factors and …

In amyotrophic lateral sclerosis (ALS) patients, loss of cellular homeostasis within cortical
and spinal cord motor neurons triggers the activation of the integrated stress response (ISR) …

Molnupiravir is a nucleoside analog antiviral that is authorized for use in the treatment of
COVID-19. For its therapeutic action, molnupiravir is converted after ingestion to the active …

Control of protein synthesis (mRNA translation) plays key roles in shaping the proteome and
in many physiological, including homeostatic, responses. One long-known translational …

The danger theory of immunity, introduced by Polly Matzinger in 1994, posits that tissue
stress, damage or infection has a decisive role in determining immune responses. Since …

The Integrated Stress Response (ISR) is an essential homeostatic signaling network that
controls the cell's biosynthetic capacity. Four ISR sensor kinases detect multiple stressors …